摘要
Abstract
Objective To evaluate the clinical efficacy and safety of nedaplatin combined with docetaxel in the treatment of elderly patients with middle and advanced non-small cell lung cancer.Methods Sixty -six elderly patients with middle and advanced non-small cell lung cancer were randomly divided into control group and treatment group,33 cases in each group.Patients in control group were given docetaxel 75 mg· m-2 intravenous drip at first day of each treatment cycle,cisplatin 30 mg · m-2 intravenous drip at 2-4 d in each cycle.Patients in treatment group were given docetaxel 75 mg · m-2 intravenous drip at day 1 of each treatment cycle and nedaplatin 30 mg · m-2 intravenous drip at 2-4 d of each cycle.Patients in two groups were given 2 cycles of treatment,each cycle 21 d.After treatment,the disease control rate,life quality scores,the levels of serum carcinoembryonic antigen (CEA),cytokeratin 19 fragment (CYFRA21-1) and neuron specific enolase(NSE),adverse drug reactions and mortality rates in two groups were compared.Results After treatment,the disease control rates in treatment group and control group were 90.91％ (30 cases/33 cases) and 66.67％ (22 cases/33 cases),with significant difference (P ＜ 0.05).The improvement rates of life quality in treatment group and control group were 78.79％ (26 cases/33 cases)and 48.48％ (16 cases/33 cases),with significant difference (P ＜0.05).The levels of CEA,CYFRA21-1 and NSE in treatment group were (5.92 ± 1.20),(4.93 ± 0.95),(13.09 ± 2.11) μg · L-1,had significant difference with those in control group,which were (10.32 ± 1.17),(9.34 ± 1.33),(19.29 ± 2.44) μg · L-1 (p ＜ 0.05).The mortality rates in treatment group and control group were 15.15％ (5 cases/33 cases)and 36.36 (12 cases/33 cases),with significant difference (P ＜ 0.05).There was no statistical significance between the two groups in adverse drug reactions (P ＞ 0.05).Conclusion The clinical effect of nedaplatin combined with docetaxel in the treatment of elderly patients with middle and advanced non-small cell lung cancer was obvious with high safety.关键词
奈达铂注射剂/多西他赛注射液/非小细胞肺癌/血清癌胚抗原/细胞角蛋白19片段Key words
nedaplatin injection/docetaxel injection/non-small cell lung cancer/serum carcinoembryonic antigen/cytokeratin 19 fragment分类
医药卫生
