中国临床药理学杂志2018，Vol.34Issue(3)：244-247,4.DOI:10.13699/j.cnki.1001-6821.2018.03.016
抗甲状腺药物与甲状腺功能亢进症所致肝功能异常的临床分析
Clinical features comparison of liver dysfunction induced by anti-thyroid drugs or hyperthyroidism
王宁 1王薇 2张红 1袁振芳 1郭晓蕙 1张俊清1
作者信息
- 1. 北京大学第一医院内分泌科,北京 100034
- 2. 保定市第一医院内分泌科,河北 保定 071000
- 折叠
摘要
Abstract
Objective To compare the clinical features of hyperthyroidism -induced liver dysfunction patients and anti-thyroid drug (ATD) induced liver dysfunction patients.Methods Clinical data of 43 liver dysfunction patients with hyperthyroidism was retrospectively analyzed.They were divided into control group (hyperthyroidism-induced liver injury group,n =24 cases) and treatment group (ATD-induced liver injury group,n =19 cases).Patients' clinical manifestations,liver function,thyroid hormone level,treatment and outcomes were analyzed.Results There were 10.53％ (2 cases/19 cases) and 16.67％ (4 cases/24 cases) patients respectively who had liver dysfunction symptoms or signs in treatment group and control group,and there was no statistically significant different (P ＞ 0.05).Elevated alanine aminotransferase (ALT) were 94.74％ and 100.00％ in treatment group and control group,and elevated aspartate transaminase (AST) were 94.74％ and 91.67％,respectively.In treatment group and control group,serum ALT level were 121.00 and 89.00 U · L-1,respectively,AST level were 78.00 and 60.50 U · L-1,respectively,the differences were statistically significant (all P ＜ 0.05).Conclusion Most liver injury patients with hyperthyroidism didn't have liver dysfunction symptoms or signs,so identification needed liver function screening.Serum ALT and AST were the sensitive tests in liver function screening.Hyperthyroidism-induced liver dysfunction was milder than that induced by ATD.关键词
甲状腺功能亢进症/抗甲状腺药物/肝功能异常Key words
hyperthyroidism/anti-thyroid drug/liver dysfunction分类
医药卫生引用本文复制引用
王宁,王薇,张红,袁振芳,郭晓蕙,张俊清..抗甲状腺药物与甲状腺功能亢进症所致肝功能异常的临床分析[J].中国临床药理学杂志,2018,34(3):244-247,4.
