中国临床药理学杂志2018，Vol.34Issue(3)：248-250,3.DOI:10.13699/j.cnki.1001-6821.2018.03.017
替硝唑片联合盐酸米诺环素软膏治疗慢性牙周炎的临床研究
Clinical trial of tinidazole tablets combined with minocycline hydrochloride ointment in the treatment of chronic periodontitis
摘要
Abstract
Objective To observe the clinical efficacy and safety of tinidazole tablets combined with minocycline hydrochloride ointment in the treatment of chronic periodontitis.Methods Ninety-four patients with chronic periodontitis were randomly divided into control and treatment groups with 47 cases per group.Control group was filled with minocycline hydrochloride ointment in the periodontal pocket,once a week.Treatment group was treated with tnidazole 250 mg per time,qd,orally,on the basis of control group.Two groups were treated for 4 weeks.The clinical efficacy,levels of soluble intercellular adhesion molecule 1 (slCAM-1),interleukin-1 β (IL-11) in gingivil,monocyte chemoattractant protein -1 (MCP-1) and adverse drug reactions were compared between two groups.Results After treatment,total effective rates of treatment and control groups were 95.74％ (45 cases / 47 cases) and 80.85％ (38 cases / 47 cases) with significant difference (P ＜ 0.05).After treatment,the main indexes in treatment and control groups were compared:sICAM-1 were (87.64 ± 11.20) and (99.87 ± 14.52) μg · L-1,IL-1β were (25.66 ±4.21) and (34.81 ±4.16) μg · L-1,MCP-1 were (28.11 ±4.65) and (39.36 ±3.66) ng · L-1,the differences were statistically significant(all P ＜0.05).The adverse drug reactions of two groups were low blood pressure and headache.The total incidences of adverse drug reactions in treatment and control groups were 12.77％ and 14.89％ without significant difference (P ＞ 0.05).Conclusion Tinidazole tablets combined with minocycline hydrochloride ointment have a definitive clinical efficacy in the treatment of chronic periodontitis,which can significantly reduce the levels sICAM-1,IL-1β and MCP-1,without increasing the incidence of adverse drug reactions.关键词
替硝唑片/盐酸米诺环素软膏/慢性牙周炎/安全性Key words
tinidazole tablet/minocycline hydrochloride ointment/chronic periodontitis/safety分类
医药卫生引用本文复制引用
张泽标,张莹,黄婉灵,陈燕茹..替硝唑片联合盐酸米诺环素软膏治疗慢性牙周炎的临床研究[J].中国临床药理学杂志,2018,34(3):248-250,3.基金项目
泉州市科技计划基金资助项目(2014Z36) （2014Z36）
