中国临床药理学杂志2018，Vol.34Issue(3)：294-296,3.DOI:10.13699/j.cnki.1001-6821.2018.03.032
利拉鲁肽对高脂喂养肥胖大鼠胰腺中核转录因子κB和蛋白酪氨酸磷酸酶1B的影响
Effects of liraglutide on expression of nuclear factor-kappa B and protein tyrosine phosphatase-1B in pancreas of the obese rats induced by high fat diet
刘洋 1赵琳1
作者信息
- 1. 解放军第309医院内分泌科,北京 100093
- 折叠
摘要
Abstract
Objective To observe the impact of liraglutide on expression of nuclear factor-kappa B (NF-κB) and protein tyrosine phosphatase -1B (PTP-1 B) in pancreas of the obese rats induced by high fat diet.Methods Obese rats model induced by high-fat-diet were randomly divided into control group (n =7 cases) and test group (n =7 cases).Another 7 normal rats were assigned to blank group.Mter modeling,test group received subcutaneous injection of liraglutide 0.6 mg · kg-1 · d-1 for 2 weeks.Control and blank groups took 2 mL subcutaneous injection of 0.9％ NaC1.We observed the expression and activity of NF-κB and PTP-1B in pancreas in three groups.Results After 2 weeks exposure,the activity of NF-κB in test,control and blank groups were 69.2,150.5 and 70.4,the expression of PTP-1B in test,control and blank groups were (1.53 ± 0.34),(1.79 ± 0.12) and (1.32 ± 0.34).The differences were statistically significant between blank group and test or blank groups (all P ＜ 0.05),and the differences were not significant between test group and blank group (all P ＞ 0.05).Conclusion Liraglutide injection can block the activation of NF-κB induced by high fat diet in pancreatic tissue thus reducing the expression of PTP-1 B,which implied that liraglutide might has been closely involved in the signal transduction pathway of NF-κB.关键词
利拉鲁肽注射液/胰岛素抵抗/蛋白酪氨酸磷酸酶1B/利拉鲁肽注射液/凝胶电泳迁移率变化分析Key words
liraglutide injection/insulin resistance/protein-tyrosine phosphatase 1 B/electrophoretic mobility shift assay分类
医药卫生引用本文复制引用
刘洋,赵琳..利拉鲁肽对高脂喂养肥胖大鼠胰腺中核转录因子κB和蛋白酪氨酸磷酸酶1B的影响[J].中国临床药理学杂志,2018,34(3):294-296,3.
