摘要
Abstract
Objective To investigate the clinical distribution and drug resistance of Staphylococcus aureus and to provide clinical reference for rational use of antibacterial drugs.Methods A total of 763 Staphylococcus aureus were isolated from various specimens of inpatients in Beijing Luhe Hospital,Capital Medical University from January 2014 to November 2016.The identification and antimicrobial susceptibility testing for Staphylococcus aureus isolates were determined by VITEK full automated microbiology analyzer,and the data of the pathogens were retrospectively analyzed with the use of WHONET 5.6 software.Results Totally 62.8％ of Staphylococcus aureus were isolated from sputum,followed by secretion (24.8％),blood(3.7％),broncho-alveolar lavage(3.7％) and so on.The distribution of department followed by intensive care unit (29.0％),general surgery (10.7％),internal respiration (9.3％),neurosurgery (8.5％) and so on.A total of 374 strains of methicillinresistant Staphylococcus aureus (MRSA)were detected,and the rate of detection in 2014-2016 were 46.6％,58.1％ and 42.6％ respectively,during the study period,the resistance of MRSA isolates to ciprofloxacin,levofloxacin,moxifloxacin were more than 80％,while to tetracycline was more than 75％,the resistance rates of MRSA isolates to clindamycin,erythromycin,rifampicin,gentamicin were 45％-55 ％,60％-70％,45 ％-85 ％,50％-70％,respectively.There were 2 linezolid resistant Staphylococcus aureus in 2015.Conclusion It is necessary to strengthen the surveillance of drug resistance due to the high drug resistant rates of Staphylococcus aureus,and antibiotics should be chosen according to the results of drug susceptibihty test.关键词
金黄色葡萄球菌/抗菌药物/耐药性Key words
Staphylococcus aureus/antimicrobials/resistance分类
医药卫生
