摘要
Abstract
Objective To evaluate the efficacy and safety of the usage of high-dose tigecycline.Methods Databases including PubMed,EmBase,The Cochrane Library,CNKI,Wanfang data and Clinical Tirals.gov were searched to select randomized controlled trials (RCTs) and observational studies that met the inclusion criteria from inception to May 2017.Two reviewers independently screened literature,extracted data,and evaluated the risk of bias of included studies.Risk ratio and 95％ confidence interval were used to present results.Meta-analysis was performed using RevMan 5.3 software to analyze patients' all-cause mortality,micro-biological clearance rate,clinical effective rate and clinical cure rate.Result A total of 5 observational studies were included,which involved 348 patients.The results of meta-analysis indicated that compared with the regular-dose group(50 mg,q12 h),the high-dose group(＞50 mg,q12 h) could significantly decrease all-cause mortality (RR =0.65,95％ CI =0.50-0.84,P ＜ 0.01),increase micro-biological clearance rate(RR =1.71,95％ CI =1.22-2.41,P ＜ 0.01),clinical effective rate (RR =1.46,95％ CI =1.13-1.87,P ＜ 0.01) and clinical cure rate (RR =1.71,95％ CI =1.71-2.48,P ＜ 0.01).Conclusion Compared with regular-dose tigecycline (50 mg,q12 h),the usage of high-dose tigecycline (＞ 50 mg,q12 h) showed superiority.关键词
替加环素/超剂量使用/安全性/有效性/系统评价Key words
tigecycline/high dosage/safety/efficacy/systematic review分类
医药卫生
