中国临床药理学杂志2018，Vol.34Issue(3)：382-386,5.DOI:10.13699/j.cnki.1001-6821.2018.03.060
内质网应激相关细胞自噬与心肌缺血再灌注损伤的研究现状
Current situation of endoplasmic reticulum stress related autophagy and myocardial ischemia/reperfusion injury
摘要
Abstract
Autophagy is a cellular degradation process for long-lived proteins and unnecessary or damaged organelles.The endoplasmic reticulum stress (ERS) response represents an adaptive mechanism that triggers the unfolded protein response to maintain ER homeostasis.Both ERS and autophagy were like double-edged sword,by which appropriate activity is cell protective,but excessive degree will trigger cell death.Several studies have suggested that ERS induced autophagy,which played the important role in myocardial ischemia reperfusion injury.This article reviews the recent advances about the effects and possible mechanism of ERS related autophagy on myocardial ischemia reperfusion injury.关键词
内质网应激/自噬/心肌/缺血再灌注损伤Key words
endoplasmic reticulum stress/autophagy/myocardium/ischemia/reperfusion injury分类
天文与地球科学引用本文复制引用
王友,朱苏红,亚白柳,刘秀华..内质网应激相关细胞自噬与心肌缺血再灌注损伤的研究现状[J].中国临床药理学杂志,2018,34(3):382-386,5.基金项目
国家自然科学基金资助项目(81703490) （81703490）
山东省自然科学基金资助项目(ZR2015HQ019) （ZR2015HQ019）
济宁医学院青年基金资助项目(z00332 （）
075901) （）
