中国临床药理学杂志2018，Vol.34Issue(5)：491-493,500,4.DOI:10.13699/j.cnki.1001-6821.2018.05.001
双环醇片治疗抗结核药物致肝功能损害的临床研究
Clinical trial of bicyclic alcohol in the treatment of patients with liver function impairment caused by antituberculosis drugs
摘要
Abstract
Objective To investigate the clinical efficacy and safety of bicyclic alcohol in the treatment of patients with antituberculotic induced liver injury(ATLI)caused by antituberculosis drugs.Methods Patients with pulmonary tuberculosis in our hospital were selected.Grouped by random number table,71 cases in the control group treated with 2HREZ/4HR[The first 2 months:isonicotinyl hydrazide (H) + rifampicin (R) +ethambutol (E) + pyrazinamide (Z);after 4 months:isonicotinyl hydrazide + rifampicin] antituberculosis combined with glucurolactone tablets,isoniazid tablets 0.3 g,qd,rifampicin capsules 0.45-0.60 g,qd,ethambutol hydrochloride tablets 0.75 g,qd,pyrazinamide tablets 0.75 g,qd,glucurolactone tablets 200 mg,tid;71 cases in the treatment group,in the basis of control group,was given bicyclol alcohol tablets 25 mg,tid.The total course of treatment was 6 months in the two groups.After the treatment,the levels of serum alanine aminotransferase (ALT),aspartate aminotransferase (AST),total bilirubin (TBil) and other liver function indexes were detected by automatic biochemical analyzer.The peripheral blood T lymphocyte levels were detected by flow cytometry.The serum malondialdehyde (MDA) levels were measured by thiobarbituric acid colorimetric assay.The levels of serum superoxide dismutase (SOD) were detected by xanthine oxidase method.The serum glutathione peroxidase (GSH-Px) levels were measured by two sulfur based double nitrobenzene formic acid assay.The incidence of ATLI and the incidence of adverse drugs reaction (ADR) were calculated.Results The levels of serum ALT,AST and TBil in the treatment and control groups after treatment were (43.16 ±4.53),(68.76 ±8.35)U · L-1;(39.64 ±5.06),(66.32 ± 8.26)U · L-1;18.05 ±2.19),(66.32 ± 8.26) μmol · L-1.Compared with control group,the difference had significantly(all P ＜0.05).The levels of CD3 +,CD4 +,CD8 + in the control group and treatment group were (61.38 ± 7.85) ％,(66.35 ± 8.16) ％;(36.93 ± 4.06) ％,(39.74 ± 4.13) ％;(35.09 ± 3.14) ％,(32.11 ± 3.22) ％;the levels of MDA in the two groups were (7.23 ± 1.02),(5.01 ± O.63)mmol · mL-1;the levels of SOD in the two groups were (432.36 ± 32.17),(497.47 ± 35.45) U · mL-1;the levels of GSH-Px in the two groups were (94.65 ± 11.88),(115.54 ± 12.12) U · L-1.Compared with control group,the difference in above factors had significantly(all P ＜0.05).The incidence of ATLI in the control group (16.90％) was higher than that in the treatment group (4.23％) with significantly(P ＜0.05);the incidence of ADR in the treatment group (7.05％) was lower than that of the control group (18.32％) with significantly (P ＜ 0.05).Conclusion Bicyclic alcohol can effectively protect the liver function of patients with pulmonary tuberculosis,and prevent the ATLI;the safety is high.关键词
双环醇/抗结核药物/肝功能损害/安全性/T淋巴细胞Key words
bicyclo alcohol/antituberculosis drugs/liver function damage/safety/T lymphocyte分类
医药卫生引用本文复制引用
李铁民,陈庆,陶磊..双环醇片治疗抗结核药物致肝功能损害的临床研究[J].中国临床药理学杂志,2018,34(5):491-493,500,4.基金项目
河北省医学科学研究重点课题计划基金资助项目(2016490) （2016490）
