中国临床药理学杂志2018，Vol.34Issue(5)：504-506,3.DOI:10.13699/j.cnki.1001-6821.2018.05.005
灯盏生脉胶囊治疗急性脑梗死的临床研究
Clinical trial of Dengzhan Shengmai capsule in the treatment of patients with acute cerebral infarction
摘要
Abstract
Objective To observe the effect of Dengzhan Shengmai capsule on carotid atherosclerotic plaque and hemodynamics in patients with cerebral infarction.Methods A total of 196 patients with acute recurrent cerebral infarction were divided into treatment group and control group.Control group was given routine treatment.Treatment group was given Dengzhan Shengmai capsule 0.36 g,3 times a day.All the patients were treated for 14 d.The clinical effect,peak systolic velocity(PSV),end diustolic velocities (EDV),resistance index (RI),pulsatility index (PI),triglyceride (TG),total cholesterol (TC),high density lipoprotein (HDL-C),low density lipoprotein (LDL-C),intima media thickness (IMT),the plate area and adverse drug reaction were compared in two groups.Results After treatment,the total effective rates of treatment group and control group were 89.80％ (88 cases/98 cases),78.57％ (77 cases/98 cases),with significant difference (P ＜ 0.05).After treatment,the plate area,IMT and carotid stenosis rate in treatment group were(13.12 ± 3.23)mm2,(0.98 ± 0.08)mm,(34.35 ± 8.52)％,had significant difference with those in control group,which were (14.84 ± 3.31)mm2,(1.13 ± 0.09) mm,(39.74 ± 9.64) ％ (P ＜ 0.05).The PSV,EDV,RI and Pl in treatment group were (78.78±15.09) cm·s-1 (23.47±3.78) cm·s-1 0.75±0.04,1.30±0.24 had significant difference with those in control group,which were (70.35 ± 14.75) cm · s-1,(22.25 ± 3.40) cm · s-1,0.81 ±0.05,1.37 ± 0.25 (P ＜ 0.05).The TG,TC,HDL-C,LDL-C in treatment group were(1.97 ± 0.19),(5.48 ±0.49),(1.58 ± 0.12),(2.04 ± 0.18)mmol · L-1,had significant difference with those in control group,which were (2.05 ± 0.20),(5.69 ± 0.51),(1.27 ± 0.10),(2.18 ± 0.21)mmol · L-1 (p ＜ 0.05).There was no obvious adverse drug reaction during the treatment in two groups.Conclusion Dengzhan Shengmai capsule can improve carotid atherosclerotic plaque,blood lipid and hemodynamics in patients with cerebral infarction,improve the prognosis of cerebral infarction and safety.关键词
灯盏生脉胶囊/动脉粥样硬化/血脂Key words
Dengzhan Shengmai capsule/artery atherosclerosis/blood lipid分类
医药卫生引用本文复制引用
黄攀,何晓英..灯盏生脉胶囊治疗急性脑梗死的临床研究[J].中国临床药理学杂志,2018,34(5):504-506,3.基金项目
国家“十一五”科技支撑计划重大专项基金资助项目(2006BAI04A02) （2006BAI04A02）
四川省应用基础研究计划基金资助项目(2014JC01662) （2014JC01662）
