中国临床药理学杂志2018，Vol.34Issue(5)：507-510,4.DOI:10.13699/j.cnki.1001-6821.2018.05.006
曲美他嗪联合美托洛尔治疗老年冠心病合并心力衰竭的临床研究
Clinical trial of trimetazidine combined with metoprolol in the treatment of elderly patients with coronary heart disease complicated with heart failure
摘要
Abstract
Objective To investigate the clinical trial of trimetazidine combined with metoprolol in the treatment of elderly patients with coronary heart disease complicated with heart failure(CHD-HF).Methods Total of 118 elderly patients with CHD-HF were randomly divided into control group and treatment group,each with 59 cases.The control group was treated with routine treatment.On the basis of control group,the treatment group was treated more with trimetazidine dihydrochloride tablets 20 mg,tid,oral + metoprolol tartrate tablets 6.25 mg,bid,oral.Two groups were all treated for 12 weeks.Myocardial remodeling indexes were measured by the color doppler ultrasound.The blood indexes were determined by immunochromatography and enzyme-linked immunosorbent assay.The treatment effects and adverse drugs reaction (ADR) were investigated.Results The improvement rate in the control group was 77.97％,it was lower than the treatment group 91.52％ with significantly(P ＜ 0.05).After treatment,the left ventricular ejection fraction of the treatment group and the control group were respectively (55.17 ±6.85)％ and (48.93 ± 6.37)％;contents of N-terminal pro-brain natriuretic peptide in the two groups were respectively (2078.96 ± 307.28),(2415.62 ± 321.47)pg· mL-1,serum hypersensitive C-reactive protein (hs-CRP) values in the two groups were respectively (4.11 ± 2.27),(6.53 ± 2.48) mg · L-1;the difference of the factors between the two groups was statistically significant (all P ＜ 0.05).Incidence of ADR in the control group and the treatment group were respectively 10.17％ (6 cases/59 cases),8.47％ (5 cases/59 cases).There was no difference in the incidence of ADR between the two groups (P ＞ 0.05).Conclusion Trimetazidine combined with metoprolol in the treatment of elderly patients with CHD-HF is effective,it can delay myocardial remodeling and myocardial injury,reduce inflammation.关键词
曲美他嗪/美托洛尔/老年冠心病合并心衰/同型半胱氨酸/心肌重塑Key words
trimetazidine/metoprolol/elderly coronary heart disease complicated with heart failure/homocysteine/myocardial remodeling分类
医药卫生引用本文复制引用
李堪董,赵圣吉,史丽..曲美他嗪联合美托洛尔治疗老年冠心病合并心力衰竭的临床研究[J].中国临床药理学杂志,2018,34(5):507-510,4.基金项目
海南省自然科学基金面上基金资助项目(20168293) （20168293）
