中国临床药理学杂志2018，Vol.34Issue(5)：532-534,3.DOI:10.13699/j.cnki.1001-6821.2018.05.013
奥美拉唑对奥拉西坦在中国健康人体中药代动力学的影响
Effects of omeprazole on pharmacokinetics of oxiracetam in healthy Chinese humans
摘要
Abstract
Objective To study the effect of omeprazole on serum concentration and pharmacokinetics of oxiracetam in Chinese healthy male volunteers and established high performance liquid chromatography (HPLC) method for determination of oxiracetam in plasma.Methods This was a single center,opened,two-way crossover study.Eight healthy Chinese volunteers were screened.The concent ration of oxiracetam in plasma was detected by HPLC before and after omeprazole administ ration.Pharmacokinetics parameters were evaluated by DAS 2.1.1 pharmacokinetics programme.Statistical analysis was performed with SPSS11.5 software.Results The results showed that after oxiracetam was used alone and incombination with omeprazole,pharmacokinetic parameters of AUC0-t,AUC0-∞,MRT0-t,MRT0-∞,tmax,Cmax,t1/2,CL/Fand V/F had no significant difference.Conclusion HPLC method for determinating of oxiracetam concentration in plasma is rapid,simple,accurate and sensitive.There is no influence on the pharmaco-kinetics of oxiracetam when combined with omeprazole in humans.关键词
奥拉西坦/奥美拉唑/药代动力学/高效液相色谱法Key words
oxiracetam/omeprazole/pharmacokinetics/high performance liquid chromatography分类
医药卫生引用本文复制引用
刘秀菊,张志清,董维冲,孙倩,赵晓娟,何文娟..奥美拉唑对奥拉西坦在中国健康人体中药代动力学的影响[J].中国临床药理学杂志,2018,34(5):532-534,3.基金项目
河北省自然科学基金资助项目(C2011206186) （C2011206186）
