中国临床药理学杂志2018，Vol.34Issue(5)：535-538,4.DOI:10.13699/j.cnki.1001-6821.2018.05.014
正电子发射型计算机断层显像剂18F-FEA-Erlotinib与11C-Erlotinib在HCC827荷瘤小鼠中的显像效果对比研究
Comparative imaging study of two positron emission computed tomography tracers of 18F-FEA-Erlotinib and 11C-Erlotinib in HCC827 tumor-bearing nude mice
摘要
Abstract
Objective To evaluate the imaging study of two positron emission computed tomography (PET) tracers of 18 F-fluoroethyl (FEA)-Erlotinib and 11C-Erlotinib in HCC827 tumor-bearing nude mice.Methods The 18F-FEA-Erlotinib and 11C-Erlotinib were synthesized by nucleophile substitution reactions.The dynamic micro-PET/CT imaging of 18F-FEA-Erlotinib for 1 h was performed in HCC827 tumor -bearing mice to evaluate the in vivo biological distribution and determine the best imaging time.Static scan of 18 F-FEA-Erlotinib and 11C-Erlotinib were performed after 1 h injection.The regions of interest (ROIs) were sketched and the semi-quantitative analysis was conducted by the percentage activity of injection dose per gram of tissue (％ ID/g).Results Dynamic micro-PET/CT imaging analysis revealed that the best static imaging time was 1 h.The resolution and contrast were good and the tumor boundaries were clear in the 18F-FEA-Erlotinib static images.In the semi-quantitative analysis,the ratios of tumor/brain,tumor/lung,tumor/bone and tumor/muscle ratios were 5.87 ± 1.21,2.97 ± 0.58,3.33 ± 0.60 and 3.80 ± 0.72 respectively for 18F-FEA-Erlotinib.Meanwhile,the ratios of the same tissues were 5.48 ± 1.45,1.10 ± 0.34,2.63 ± 0.54 and 2.10 ± 0.63respectively for 11C-Erlotinib.The resolution of 18F-FEA-Erlotinib imaging was better than 11C-Erlotinib images.Conclusion The uptake of 18F-FEA-Erlotinib in HCC827 tumor was visual obviously.The image resolution and the target/non-target ratio of 18F-FEA-Erlotinib was higher than 11C-Erlotinib.关键词
非小细胞肺癌/HCC827细胞/[18F]氟乙基-埃罗替尼/[11C]埃罗替尼/正电子发射型计算机断层显像Key words
non-small cell lung cancer/HCC827 cell/18 F-flouroetingl-Erlotinib/11C-Erlotinib/positron emission computed tomography imaging分类
医药卫生引用本文复制引用
黄顺,韩彦江,胡孔珍,陈莉,孙朋辉,吴湖炳,王全师,赵肃清,郑希..正电子发射型计算机断层显像剂18F-FEA-Erlotinib与11C-Erlotinib在HCC827荷瘤小鼠中的显像效果对比研究[J].中国临床药理学杂志,2018,34(5):535-538,4.基金项目
国家自然科学基金资助项目(81701729) （81701729）
广东省科技计划基金资助项目(2014A020212175) （2014A020212175）
广东省医学科研基金资助项目(A2015525) （A2015525）
