中国临床药理学杂志2018，Vol.34Issue(5)：555-557,561,4.DOI:10.13699/j.cnki.1001-6821.2018.05.019
补阳还五汤对动脉粥样硬化大鼠主动脉超微结构的影响
Effect of Buyanghanwutang on the ultrastructure of aorta in atherosclerosis rats
摘要
Abstract
Objective To observe the effect of Buyanghanwutang (BYHWT) on the ultrastructure of aorta in atherosclerosis (AS) rats.Methods Establish AS rat model by high fat diets and vitamin D3.Forty rats were randomly divided into four groups:model group,control group (simvastatin 0.6 mg · kg-1),low and high dose test groups (BYHWT 10,20 g · kg-1),10 rats in each group;the other 20 rats were randomly divided into blank group and prevention group (BYHWT 10 g · kg-1,administered with drugs during the modeling).After the successful modeling and 28-day intervention,the ultrastructure of endothelial cells and smooth muscle cell of aorta in AS rats was observed under transmission electron microscope.Results Compared with the model group,the atherosclerosis of aorta in the BYHWT high-dose test group,the control group and the prevention group was significantly lighter.It was suggested that the aortic endothelial cells in the BYHWT high-dose test group,the control group and the prevention group were more normal in forms and intact;internal elastic membrane was even and uniform fiat.Smooth muscle cells in the medial membrane were in alignment;meanwhile,it was found that in the model group there were foam cells in endothelium and subendothelium;fibrous atherosclerotic plaques were formed;the thickness of internal elastic membrane was uneven,even absent;and there were hyperplasia of cells in smooth muscle cells arranged in disorder;cytoplasm was full of lipids.Conclusion Buyanghanwu Tang can improve and correct the ultrastructure of endothelial cells and smooth muscle cells of aorta in AS rats.关键词
补阳还五汤/动脉粥样硬化/主动脉超微结构Key words
Buyanghanwutang/atherosclerosis/ultrastructure of aorta分类
医药卫生引用本文复制引用
张红珍,郭春兰,焦瑞,王青,李丽,张英,钱艳,张鑫..补阳还五汤对动脉粥样硬化大鼠主动脉超微结构的影响[J].中国临床药理学杂志,2018,34(5):555-557,561,4.基金项目
国家自然科学基金资助项目(81373532) （81373532）
山西省黄芪资源产业化及产业国际化协同创新中心基金资助项目(HQXTCXZX2016-024) （HQXTCXZX2016-024）
