中国畜牧杂志2018，Vol.54Issue(4)：20-23,4.DOI:10.19556/j.0258-7033.2018-04-020
胰淀素调控生理机能的研究进展
Research Progress on Amylin Control Physiological Functions
摘要
Abstract
Amylin is an important player in the balance of energy metabolism.Amylin reduces eating via a meal size effect by promoting meal-ending satiation.This effect seems to depend on a direct action in the area postrema (AP),which is an area rich in amylin receptors.Subsequent to the activation of AP neurons,the neural signal is conveyed to the forebrain via relays involving the nucleus of the solitary tract (NTS) and the lateral parabrachial nucleus(LPBN) to the lateral hypothalamic area (LHA) and other hypothalamic nuclei.While the NTS and LPBN seem to be necessary for amylin's eating inhibitory effect,the role of the LHA has not yet been fully investigated.Amylin may also act as anadiposity signal.Plasma levels of amylin are higher in obese individuals,and chronic infusion of amylin into the brain reduces body weight gain and adiposity;chronic infusion of an amylin receptor antagonist into the brain increases body adiposity.Therefore,amylin is a potential target for the treatment of obesity.In this paper,the progress on the study of energy metabolism was reviewed.关键词
Amylin/能量代谢/最后区/下丘脑Key words
Amylin/Energy metabolism/Area postrema/Hypothalamic分类
医药卫生引用本文复制引用
郭志凯,范奎奎,潘登,李强,钱英红,杜晨光..胰淀素调控生理机能的研究进展[J].中国畜牧杂志,2018,54(4):20-23,4.基金项目
国家自然科学基金(31660701、31160455) （31660701、31160455）
