中华耳科学杂志2018，Vol.16Issue(2)：141-144,4.DOI:10.3969/j.issn.1672-2922.2018.02.003
囊性前庭神经鞘膜瘤超微病理特性分析
Ultrastructural Pathological Features of Cystic Vestibular Schwannoma
摘要
Abstract
Objective Experiments were conducted to demonstrate differences of ultrastructural pathological changes and biological characteristics between cystic and solid vestibular schwannoma. Methods Cystic vestibular schwannoma (CVS) specimens collected from 15 patients (study group), as well as specimens of solid vestibular schwannoma(SVS)(control group,n=15)were studied by light microscopy and transmission electron microscopy.The specimens were stained with LC3 monoclonal antibodies to demonstrate expression of autophagy. Results Under the electron microscope,typical autophagosomes were seen in CVS,but not in SVS.The rates of positive LC3 immunohis-tochemistry staining was 13.3%,60.0% and 73.3% in SVS tumor body,CVS tumor body and CVS cyst wall,respective-ly.In SVS,the expression of LC3 was significantly lower than in CVS.Conclusions The regulation of autophagy may play an important role in the cystic degeneration of vestibular schwannoma.关键词
前庭神经鞘膜瘤/超微病理/自噬/囊性变Key words
Vestibular Schwannoma/Ultrastructural Pathology/Autophagy/Cystic Degeneration分类
医药卫生引用本文复制引用
严爽,火子榕,尹晓玲,张治华..囊性前庭神经鞘膜瘤超微病理特性分析[J].中华耳科学杂志,2018,16(2):141-144,4.基金项目
国家自然科学基金面上项目(81470681) （81470681）
上海人才发展资金资助项目(2017120) National Natural Science Foundation of China(81470681) （2017120）
Shanghai Talent Development Funding Project(2017120) （2017120）
