中华耳科学杂志2018，Vol.16Issue(2)：145-149,5.DOI:10.3969/j.issn.1672-2922.2018.02.004
顺铂耳毒性机制及抗氧化药物局部应用的预防作用
Cisplatin Ototoxicity Mechanisms and Prevention with Locally Delivered Antioxidant Drugs
摘要
Abstract
Cisplatin is a widely used and effective drug for the treatment of various solid tumors.Unfortunately, its severe side-effects have also impacted patients,especially its often bilateral,progressive,irreversible and dose-depen-dent ototoxicity.Current evidence indicates that cisplatin triggers the production of reactive oxygen species(ROS)in tar-get tissues in the inner ear.A large number of agents that protect against cisplatin-induced ototoxicity have been success-fully tested in cell culture and animal models.However,many of them interfere with the therapeutic effects of cisplatin, and therefore are not suitable for systemic administration in clinical practice. Until now, none of them has been ap-proved by the FDA.Consequently,local administration strategies,namely intratympanic administration,have been de-veloped to achieve otoprotection,without reducing the antitumoral effects of cisplatin.This review summarizes the clini-cal and experimental studies of ciaplatin ototoxicity,including details of the molecular mechanisms of action,to gain in-sight for future drug development in this field.关键词
顺铂/耳毒性/药物/预防Key words
Cisplatin/Ototoxicity/Antioxidant Drugs/Prevention分类
医药卫生引用本文复制引用
於得红,汪雪玲,陈聿名,吴皓..顺铂耳毒性机制及抗氧化药物局部应用的预防作用[J].中华耳科学杂志,2018,16(2):145-149,5.基金项目
国家自然科学基金青年项目(81700899),上海交通大学医学院"临床专职科研队伍"基金(20171919),上海市耳鼻疾病转化医学重点实验室(14DZ2260300),国家自然科学基金重点项目(81330023) This work was supported by the National Natural Science Foundation of China(No.81700899),Shanghai Municipal Ed-ucation Commission-Gaofeng Clinical Medicine Grant Support(No.20171919),Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases(14DZ2260300),the State Key Program of National Natural Science Foundation of China(No.81330023). （81700899）
