中华耳科学杂志2018，Vol.16Issue(2)：155-159,5.DOI:10.3969/j.issn.1672-2922.2018.02.006
人工耳蜗植入与骨髓间充质干细胞移植联合治疗感音神经性耳聋研究进展
Research Advances on Convergence of Cochlear Implantation with Bone Mesenchymal Stem Cell Transplantation in Therapy of Sensorineural Hearing Loss
摘要
Abstract
Sensorineural hearing loss(SNHL)is a difficult and hot issue in the field of otology.The damage of in-ner ear hair cells and spiral ganglion neurons(SGNs)is one of the major factors leading to SNHL.Treatment or rehabili-tation for sensorineural hearing loss can be achieved with hearing aids or cochlear implants,but none of them can re-store the normal auditory structures and the outcomes are often unsatisfactory.In recent years,some scholars have ques-tioned whether cochlear implants can be combined with stem cell transplantation to improve the efficacy of cochlear im-plants.Bone mesenchymal stem cells(BMSCs)have become a research hotspot in modern biology and medicine in re-cent years due to their high amplification potentials,ease to isolate and culture,low immunogenicity and immunomodu-latory functions.BMSCs have been confirmed by a number of clinical trials to have great potentials for clinical applica-tions in tissue damage repair,such as for myocardial infarction,brain injury,and cartilage and bone damage.In this re-view,we will review the relationship between the number of SGNs and efficacy of cochlear implants and transplantation of BMSCs for SGN regeneration/repair,covering challenges in combining cochlear implantation and stem cell transplan-tation.关键词
感音神经性耳聋/骨髓间充质干细胞/人工耳蜗/研究进展Key words
Sensorineural Hearing Loss(SNHL)/Bone Mesenchymal Stem Cells(BMSCs)/Cochlear Implant/Research Advance分类
医药卫生引用本文复制引用
尹晓玲,火子榕,严爽,张治华..人工耳蜗植入与骨髓间充质干细胞移植联合治疗感音神经性耳聋研究进展[J].中华耳科学杂志,2018,16(2):155-159,5.基金项目
国家自然科学基金面上项目(81470681) （81470681）
本研究工作得到了上海市人才发展资金资助项目的支持,编号为2017120 This work was supported by grants from the National Natural Science Foundation of China(No.81470681),Shanghai Talent De-velopment Funding Project(No.2017120). （No.81470681）
