中华耳科学杂志2018，Vol.16Issue(2)：212-215,4.DOI:10.3969/j.issn.1672-2922.2018.02.016
Dot1l在正常豚鼠耳蜗中的表达
Expression of Dot1l in Guinea Pig Cochlea
摘要
Abstract
Objective To study the expression of Disruptor of telomeric silencing 1-like (Dot1l) in cochleae of guinea pigs.Methods Six guinea pigs with normal hearing were sacrificed and expression of Dot1l in the cochlea was evaluated by immunohistochemistry.Rusults Dot1l was found in the stria vascularis,Reissner's membrane,spiral liga-ment,organ of Corti,spiral limbus and spiral ganglion.From basal turn to apical turn,Dot1l expression in the spiral liga-ment significantly decreased(F=8.29,P=0.0091),while that in the spiral ganglion significantly increased(F=6.22,P=0.0201).Conclusion Dot1l,a protein that may be involved in regulation of ENaC expression,exists in the cochlea of guinea pigs.Dot1l in the cochlea may be involved in regulation of ENaC,and thus related to endolymph regulation.关键词
H3K79/Dot1l/ENaC/内淋巴循环Key words
H3K79/Dot1l/ENaC/Endolymph Regulation分类
医药卫生引用本文复制引用
章碧云,秦丽,罗小莉,钟时勋..Dot1l在正常豚鼠耳蜗中的表达[J].中华耳科学杂志,2018,16(2):212-215,4.基金项目
及编号:重庆市自然科学基金项目资助(cstc2013jcy-jA10034) Chongqing Natural Science Foundation(cstc2013jcyjA10034).Fund projects:Chongqing Natural Science Foundation(cstc2013jcyjA10034). （cstc2013jcy-jA10034）
