组织工程与重建外科杂志2018，Vol.14Issue(2)：97-100,4.
脂肪干细胞在同种异体复合组织移植中的作用及其临床应用展望
Effectiveness and Clinical Perspectives of Adipose Derived Stem Cell Based Therapy in Vascularized Composite Allotransplantation
王尹民 1王秀侠 1刘菲 1杨军1
作者信息
- 1. 200011上海市 上海交通大学医学院附属第九人民医院整复外科
- 折叠
摘要
Abstract
Vascularized composite allograft transplantation is an important method in tissue repair and reconstruction. However, the side effects of immunosuppressive therapy remains the great burden of these patients and lacks an appropriate solution. There is a growing attention to the emerging cell therapy, like mesenchymal stem cell, especially adipose derived mesenchymal stem cell,in combine with immunosuppressive agents which may prolong the graft survival and reduce the side effects of immunosuppressor. The underlying mechanism of adipose derived mesenchymal stem cell therapy may include the paracrine of immunomodulatory molecules, the induction of regulatory T cells, mixed chimerism and the reduction of ischemia reperfusion injury. Moreover, the safety, timing and dosage of adipose derived stem cell should be tested and determined before clinical application.关键词
脂肪干细胞/同种异体复合组织移植/免疫调节/细胞治疗Key words
Adipose derived mesenchymal stem cell/Vascularized composite allotransplantation/Immunomodulation/Cell therapy分类
医药卫生引用本文复制引用
王尹民,王秀侠,刘菲,杨军..脂肪干细胞在同种异体复合组织移植中的作用及其临床应用展望[J].组织工程与重建外科杂志,2018,14(2):97-100,4.
