北京大学学报（医学版）2018，Vol.50Issue(2)：381-385,5.DOI:10.3969/j.issn.1671-167X.2018.02.031
队列数据共享的必要性与可行性
Necessity and feasibility of data sharing of cohort studies
摘要
Abstract
Cohort study is one of the important epidemiological methods which plays an irreplaceable status and role in etiological study.Using cohort study design,we can accurately and continuously collect genetic and environmental information,and identify and validate omics biomarkers to provide evidences for precision public health and medicine.However,results from a new cohort would not be available for at least ten years,as five years would be needed for funding,planning and enrolment,and another five for following up even the earliest analyses of the most common diseases;results for most cancers would take longer,with an unaffordable budget for many research investigators or institutions.That brings an alternative strategy of using existing cohort studies by sharing data between each other.Data sharing of cohort studies would be beneficial in many ways.Data sharing of cohort studies has the potential to make large samples unattainable in a single study,increase statistical power,enable more accurate and detailed subgroup analysis,increase the generalizability of results.It would also facilitate exchange of experiences and learning from each other,avoid for duplicated research and effectively promote the second use of existing data (i.e.using old data to discover new results).The data sharing would save staff recruitment,follow-up,laboratory analysis of the cost,with a high cost-benefit returns and economies of scale.Data sharing enables cross-validation and repeated verification across different data.Many international research funding agencies or leading research groups have also reached consensus on the principles and goals for promoting the sharing of medical research data.Due to rapid development of cohort studies in the past decades,China already has the basis for data sharing of cohort studies.Unfortunately,most of the existing cohort studies are self-contained,independent,lack of visibility,with insufficient co-operation and data sharing between each other.The academic value of the existing data collected in these cohort studies have not been fully exploited and utilized so far.Therefore,the China Cohort Consortium is trying to establish a multi-level three-dimensional cooperation and data sharing strategy.We hope that it will encourage researchers from public health,clinical and other related fields to work more closely through providing data management,data integration,data interaction,tools development,data repositories and other functions.关键词
队列/数据共享/中国队列共享平台Key words
Cohort/Data sharing/China Cohort Consortium分类
医药卫生引用本文复制引用
杨羽,赵厚宇,詹思延..队列数据共享的必要性与可行性[J].北京大学学报（医学版）,2018,50(2):381-385,5.基金项目
国家自然科学基金(91646107)、国家重点研发计划(2016YFC0901105)资助 Supported by the National Natural Science Foundation of China (91646107) and the National Key Research and Development Plan (2016YFC0901105) （91646107）
