川北医学院学报2018，Vol.33Issue(2)：148-153,6.DOI:10.3969/j.issn.1005-3697.2018.02.002
基于GRADE系统的两种钙通道阻滞剂联合治疗高血压的循证实践
Evidence-based practice of dual calcium channel blockers treating hyper-tension based on GRADE system
摘要
Abstract
Objective:Applying GRADE system to evidence-based evaluate the rationality of dual calcium channel blockers (CCB) treating hypertension,we try to establish a feasible method of evidence-based evaluation of pharmacotherapeutic schemes,and promote the rational use of medicines.Methods:The two kinds of CCB combined treatment of the clinical problem of hypertension ac-cording to the principle of PICO conversion,retrieval related database,according to the set standards for screening and evidence of qual-ity rating results.Then,the evidence quality of original research was rated and each outcome index was comprehensively evaluated.Fi-nally,the rationality of the medicine treatment scheme was evaluated.Results:Dual CCB,namely dihydropyridine(DHP) and nondihy-dropyridine(NDHP),in the treatment of hypertension was graded as evidence-based medicine,but the evidence quality was relatively low.Compared with DHP,dual CCB reduced both blood pressure and the heart rate.Compared with NDHP,dual CCB reduced blood pressure and increased the heart rate.Dual CCB had lower incidence of adverse drug reaction in comparison with monotherapy.Conclu-sion:The GRADE system is an effective method of evidence-based evaluation of pharmacotherapeutic schemes.This result shows that combination therapy of DHP and NDHP increased the therapeutic effects and decreased the adverse drug reactions.However,since the evidence quality is relatively low,more large-sample,multicenter,and high-quality RCTs are required to further proof the efficiency and safety of this combined therapy.关键词
循证实践/GRADE系统/高血压/钙通道阻滞剂/二氢吡啶类/非二氢吡啶类Key words
Evidence-based practice/GRADE system/Hypertension/Calcium channel blockers/Dihydropyridine/Nondihydropy-ridine分类
医药卫生引用本文复制引用
杨忆,匡扶,王娜,付钰莹,余娴..基于GRADE系统的两种钙通道阻滞剂联合治疗高血压的循证实践[J].川北医学院学报,2018,33(2):148-153,6.基金项目
重庆市卫生计生委重点项目(2016ZDXM010) （2016ZDXM010）
