川北医学院学报2018，Vol.33Issue(2)：166-168,3.DOI:10.3969/j.issn.1005-3697.2018.02.006
阿司匹林联合大剂量丙种球蛋白治疗小儿川崎病的疗效及对血清脑利钠肽指标的影响
The effect of aspirin combined with high dose of intravenous immunoglob-ulin in treatment of children with kawasaki disease and its effects on serum brain natriuretic peptide index
摘要
Abstract
Objective:Explore the effect of aspirin combined with high dose of intravenous immunoglobulin in treatment of chil-dren with kawasaki disease and its effects on serum brain natriuretic peptide index.Methods:100 cases of Kawasaki disease were se-lected,and randomly divided into observation group and control group,each group had 50 cases.On the basis of the same dose of aspirin treatment,the observation group had given high-dose gamma globulin (1 g/kg) intravenous injection,while the control group received conventional dose (400 mg/kg).The serum levels of brain natriuretic peptide(BNP) and inflammatory markers,the improvement time of clinical symptoms and signs,the clinical efficacy and the incidence of cardiovascular complications were compared between the two groups.Results:The levels of BNP,CRP,ESR and PLT in the observation group were significantly lower than those in the control group,the difference was statistically significant (P<0.05).The recovery time of fever,mucosal hyperemia,swelling of lymph node in neck and foot scleredema in observation group were significantly shorter than that in the control group,the difference was statistically significant(P<0.05).The total clinical effective rate (94.0%) in observation group was higher than the effective rate(80.0%) in control group,the difference was statistically significant(χ2=5.892,P=0.014).The incidence of cardiovascular complications (8%) was lower than the incidence (24%) in the control group,the difference was statistically significant(χ2=6.23,P=0.011).Conclu-sion:Aspirin combined with large dose of intravenous immunoglobulin for children with Kawasaki disease can effectively reduce serum inflammatory markers and BNP level,shorten the recovery time of symptoms,improve clinical efficiency,reduce the incidence of cardio-vascular complications,is worthy of clinical application.关键词
阿司匹林/丙种免疫球蛋白/血清脑利钠肽/川崎病Key words
Aspirin/Immunoglobulin/Brain natriuretic peptide/Kawasaki disease分类
医药卫生引用本文复制引用
赵有丽,刘彩霞..阿司匹林联合大剂量丙种球蛋白治疗小儿川崎病的疗效及对血清脑利钠肽指标的影响[J].川北医学院学报,2018,33(2):166-168,3.基金项目
陕西省汉中市科技局项目(2013hzzx-39) （2013hzzx-39）
