川北医学院学报2018，Vol.33Issue(2)：184-187,4.DOI:10.3969/j.issn.1005-3697.2018.02.011
HIV/AIDS患者与HBV、HCV共感染对外周血病毒载量及T淋巴细胞亚群表达影响的相关性分析
Correlation analysis on the influence of HIV/AIDS patients with HBV and HCV co-infection on peripheral viral loads and the expression of T lym-phocyte subgroups
刘娇 1王川林 1古雪 1梅怡晗 2李铃 1梅小平1
作者信息
- 1. 川北医学院附属医院感染科,四川 南充 637000
- 2. 首都医科大学,北京 100069
- 折叠
摘要
Abstract
Objective:Analyzing the influence of HIV/AIDS patients with HBV and HCV co-infection on peripheral viral loads and the expression level of T lymphocyte subgroups.Methods:The peripheral blood CD4 +T cells and CD8 +T cells expression levels, the ratio of CD4 +T/CD8 +T cells,HIV RNA、HBV DNA and HCV RNA viral loads of 115 cases of HIV infected,HIV/HBV,HIV/HCV and HIV/HBV/HCV co-infected patients were comparatively analyzed by flow cytometry and PCR.Results:The incidence of abnormal liver function,liver failure and death increased as the expression levels of CD4 +T cells decreased and the difference was statistically significant among three groups(P<0.05).The difference of CD4 +T cell counts and CD8 +T cell counts was statistically different com-paring two of HIV groups,HIV/HBVgroup,HIV/HCVgroup and HIV/HBV/HCV group(P<0.05).With different types of HIV/HBV and HIV/HCV and HIV/HBV/HCV infection compared between groups,in addition to the HIV/HBV co-infection with HIV/HCV co-infection group compared differences no statistical significance (P>0.05),the rest of the comparative differences between every two groups have statistical significance(P<0.05).HIV,HIV/HBV HIV/HCV and HIV/HBV/HCV infection group of CD4 +T and CD8 +T and their respective group HIV RNA loads more negatively related(P<0.05).Conclusion:HIV merger of HBV and HCV infections can affect the level of peripheral blood T lymphocyte expression and biological function,reducing the effection on virus removal,promote HIV RNA copy,accelerate the immune injury of HIV/AIDS,increasing the disease process.关键词
HIV/AIDS/乙型肝炎病毒/丙型肝炎病毒/合并感染/T淋巴细胞Key words
HIV/AIDS/Hepatitis b virus(HBV)/Hepatitis c virus (HCV)/Merge infection/T lymphocytes分类
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刘娇,王川林,古雪,梅怡晗,李铃,梅小平..HIV/AIDS患者与HBV、HCV共感染对外周血病毒载量及T淋巴细胞亚群表达影响的相关性分析[J].川北医学院学报,2018,33(2):184-187,4.
