川北医学院学报2018，Vol.33Issue(2)：192-195,4.DOI:10.3969/j.issn.1005-3697.2018.02.013
回收式自体输血与异体输血对凝血功能、免疫功能及炎症因子的影响
Influence of intraoperative autotransfusion and allogeneic transfusion on coagulation function,immune function and inflammatory factors in pa-tients with cardiac surgery
摘要
Abstract
Objective:To study the influence of intraoperative autotransfusion and allogeneic transfusion on coagulation function, immune function and inflammatory factors in patients with cardiac surgery.Methods:74 patients undergoing cardiac surgery in hospital between June 2014 and February 2017 were selected as the research subjects and randomly divided into two groups,autologous group re-ceived intraoperative autotransfusion and allogeneic group received allogeneic transfusion.The blood coagulation function indexes,im-mune function indexes and inflammatory response indexes of the two groups were measured 1 day and 5 days after surgery.Results:1 day and 5 days after surgery,APTT,TTnd PT levels as well as D-D and FDP contents of autologous group were not significantly different from those of allogeneic group.1 day and 5 days after surgery,peripheral blood CD3 +CD4 +T cell,CD3 +CD8 +T cell and CD16 +CD56 +NK cell contents were lower than those before surgery,peripheral blood TLR2 +cell and TLR4 +cell contents as well as serum sCD40L,CINC-1,TNF-α and IL-6 contents were higher than those before surgery and peripheral blood CD3 +CD4 +T cell,CD3 +CD8 +T cell and CD16 +CD56 +NK cell contents were greatly higher than those of allogeneic group,and peripheral blood TLR2 +cell and TLR4 +cell contents as well as serum sCD40L,CINC-1,TNF-α and IL-6 contents were greatly lower than those of allogeneic group. Conclusion:Intraoperative autotransfusion for cardiac surgery can improve the immune function and inhibit the inflammatory response without affecting the coagulation function.关键词
回收式自体输血/异体输血/凝血功能/免疫功能/炎症反应Key words
Intraoperative autotransfusion/Allogeneic transfusion/Coagulation function/Immune function/Inflammatory re-sponse分类
医药卫生引用本文复制引用
屈晶磊,杨远征..回收式自体输血与异体输血对凝血功能、免疫功能及炎症因子的影响[J].川北医学院学报,2018,33(2):192-195,4.基金项目
海南省卫生计生行业科研项目资助(14A210207) （14A210207）
