川北医学院学报2018，Vol.33Issue(2)：206-209,4.DOI:10.3969/j.issn.1005-3697.2018.02.016
支气管哮喘患儿血清中Eotaxin、IL-13的表达水平及临床意义
Expression and clinical significance of Eotaxin,IL-13 in the serum of chil-dren with bronchial asthma
魏淑丽 1黄雪玲2
作者信息
- 1. 厦门医学院临床医学系,福建 厦门 361023
- 2. 厦门医学院附属厦门市第二医院儿科,福建 厦门 361021
- 折叠
摘要
Abstract
Objective:To explore the interaction and relationship of Eotaxin and IL-13 in children with bronchial asthma.Meth-ods:24 children with bronchial asthma(study group) and 30 healthy children(healthy control group) were selected.IL-13 and Eotaxin levels of the two groups were measured by sandwich ELISA,and the pulmonary function of patients in study group was detected at the same time.Results:There was a significant difference in serum Eotaxin and IL-13 expression of acute attack stage and asthma remission stage compared with healthy control group (P<0.05).In the children with asthma,Eotaxin and IL-13 were positively related to each other in the acute phase and the asthma remission stage.The serum levels of Eotaxin and IL-13 were negatively correlated with the one second forced expiratory volume (FEV1) and peak expiratory flow (PEF) in the acute and remission stage of asthma.Conclusion:Eotaxin and IL-13 interact with each other during the pathogenesis of bronchial asthma and participate in the pathophysiological changes of children with asthma.Eotaxin and IL-13 can be used as an objective index to assess the severity of the disease and evaluate the effect of asthma in children with asthma.关键词
支气管哮喘/白细胞介素13/肺功能测定/嗜酸性粒细胞趋化因子Key words
Bronchial asthma/IL-13/Pulmonary Functios Testing/Eotaxin分类
医药卫生引用本文复制引用
魏淑丽,黄雪玲..支气管哮喘患儿血清中Eotaxin、IL-13的表达水平及临床意义[J].川北医学院学报,2018,33(2):206-209,4.
