重庆医学2018，Vol.47Issue(13)：1705-1708,4.DOI:10.3969/j.issn.1671-8348.2018.13.001
探讨γδT细胞在小鼠胰岛移植排斥反应中的作用
Study on the effect of γδT cell activated in mice islet transplantation rejection
摘要
Abstract
Objective After the islet transplantation,observed blood glucose and survival time in the islet transplantation mice model to explore the effect of intestinal epithelial γδT cell in islet transplantation rejection.Methods Established the mice model of islet transplantation,divided into wild type mice group,γδ gene knockout mice group and γδ gene knockout γδT cell reinfusion mice group,observed blood glucose in 1,3,5,7,9,11,13,15,17,19,21,23,25,27,29 days after surgery and pathological conditions aft er two weeks of transplantation.Results After transplantation,the rising blood glucose of wild type mice group and γδ gene knockout γδT cell reinfusion mice group were significantly slower than that of γδ gene knockout mice group (P＜0.05),but there was no significant difference in between two groups (P＞0.05).The survival time of wild-type mice group was (27±2) days,and γδ gene knockout γδT cell reinfusion mice group was (24±1) days,they were significantly longer than (17±3) days of γδ gene knockout mice group (P＜ 0.05).Conclusion As a special kind of T cells,γδT intestinal epithelial cell plays an important role in the islet transplantation rejection.关键词
γδT细胞/血糖/胰岛移植/移植排斥反应Key words
γδT cell/blood glucose/islet transplantation/transplant rejection分类
医药卫生引用本文复制引用
李传贵,宋亚军,杨加彩,黄赤兵..探讨γδT细胞在小鼠胰岛移植排斥反应中的作用[J].重庆医学,2018,47(13):1705-1708,4.基金项目
国家自然科学基金资助项目(81370845). （81370845）
