重庆医学2018，Vol.47Issue(13)：1709-1711,1715,4.DOI:10.3969/j.issn.1671-8348.2018.13.002
含HOE642的新型器官保存液对离体兔肺移植供肺细胞凋亡的影响
Effect of a new organ preservation solution with HOE642 on the apoptosis of the donor lung from a modified lung transplantation model of rabbits
摘要
Abstract
Objective To explore the effect of a new organ preservation solution with HOE642 on the apoptosis of the donor lung from a modified lung transplantation model of rabbits.Methods 24 male rabbits were divided into two groups [low potassium dextran (LPD) group and HOE group],established rabbit models for next 2-h reperfusion using LPD solution or new organ preservation solution.Detected the levles of apoptosis index and caspase-3,the expression of Fas/Fas-L and Bcl-2/Bax.Results Compared with LPD group,HOE group revealed significant lower level of apoptosis index and caspase-3 (P＜0.05),lower expression of Fas/Fas-L and Bax,and higher expression of Bcl-2 (P＜0.05).Conclusion The potential donor lung protective mechanism offered by the new organ preservation solution with HOE642 might be the inhibition of apoptosis via both intrinsic and extrinsic pathways.关键词
器官保存液/肺移植/细胞凋亡/HOE642Key words
organ preservation solutions/lung transplantation/apoptosis/HOE642分类
医药卫生引用本文复制引用
余得水,龚添庆,周文琴,郑剑桥,刘斌..含HOE642的新型器官保存液对离体兔肺移植供肺细胞凋亡的影响[J].重庆医学,2018,47(13):1709-1711,1715,4.基金项目
国家自然科学基金资助项目(30972862). （30972862）
