分析测试学报2018，Vol.37Issue(4)：492-495,4.DOI:10.3969/j.issn.1004-4957.2018.04.018
核磁共振定量法测定利培酮含量
Determination of Risperidone by Quantitative Nuclear Magnetic Resonance
摘要
Abstract
Proton nuclear magnetic resonance (qHNMR) and fluorine nuclear magnetic resonance (qFNMR) were employed to determine the content of risperidone.The 1 H NMR spectra were collected at 300 K within 4.0 s acquisition time,15 s relaxation delay and 32 scanning times.Proton signal peaks at δ 7.29-7.35 of risperidone and δ 6.02 of maleic acid were served as quantitative peaks.The 19F NMR spectra were obtained at 300 K by using 12 500.0 Hz spectral width and-43 662.7 Hz transmitter frequency offset (O1).4-bromo-2-fluorine acetanilide was employed as the internal standard.The results of qHNMR and qFNMR were generally consistent with that of the mass balance method.Therefore,quantitative nuclear magnetic resonance could be used for the quantitative determination of risperidone.关键词
利培酮/核磁共振法/氢核磁共振定量法/氟核磁共振定量法Key words
risperidone/nuclear magnetic resonance/1H NMR/19F NMR分类
数理科学引用本文复制引用
郭留城,郝海军,杜利月..核磁共振定量法测定利培酮含量[J].分析测试学报,2018,37(4):492-495,4.基金项目
2017年度河南省高等学校青年骨干教师培养计划(2017GGJS286) （2017GGJS286）
