国际生殖健康/计划生育杂志2018，Vol.37Issue(2)：167-171,5.
多囊卵巢综合征胰岛素抵抗机制研究进展
Research Progress in the Mechanism of Insulin Resistance in Polycystic Ovary Syndrome
摘要
Abstract
Polycystic ovary syndrome (PCOS),a gynecological endocrine disease with high heterogeneity,is characterized by hyperandrogenemia,hyperinsulinemia and/or abnormal ovulation.Insulin resistance (IR) is considered as a part of the pathogenesis of PCOS,and PCOS patients often show hyperinsulinemia.It is helpful for understanding the pathogenesis and prognosis of PCOS to explore the mechanism of IR,and for preventing the complications,especially cardiovascular disease.The molecular biological basis of IR in PCOS women is related to the gene of insulin receptor(INSR),the regulation of gene expression and the intracellular insulin signaling pathway.We will mainly discuss the polymorphism of related genes,mitochondrial transport RNA (mt-tRNA),microRNA,INSR and its downstream signals such as PI3K and MAPK,and some post-receptor substances which can regulate the insulin sensibility.关键词
多囊卵巢综合征/受体,胰岛素/信号传导/胰岛素抵抗Key words
Polycystic ovary syndrome/Receptor, insulin/Signal transduction/Insulin resistance引用本文复制引用
张飞祥..多囊卵巢综合征胰岛素抵抗机制研究进展[J].国际生殖健康/计划生育杂志,2018,37(2):167-171,5.基金项目
上海市科学技术委员会上海市自然科学基金面上项目(17ZR1403100) （17ZR1403100）
上海市卫生和计划生育委员会科研基金面上项目(201540214) （201540214）
