广西医科大学学报2018，Vol.35Issue(4)：450-454,5.DOI:10.16190/j.cnki.45-1211/r.2018.04.007
新型铜胺纳米材料抑制3种人类癌细胞增殖的实验研究
Inhibition effect of novel copper-cysteamine nanoparticles on the proliferation of three human cancer cells
摘要
Abstract
Objective:To study the effect of Cu-Cy-Nanos on the growth of different tumor cells,and to provide a new theoretical basis and experimental basis for the follow-up study.Methods:Singlet oxygen was detected by RNO decolorization assay.MTT assay was used to compare the sensitivity of different tumor cells to Cu-Cy-Nanos.Results:Cu-Cy-Nanos could produce singlet oxygen by the excitation of ultraviolet light.MTT results showed that Cu-Cy-Nanos could inhibit the growth of three different tumor cells (P＜0.05).However,the inhibitory effect was different between these three cancer cells.The growth of hepatocellular carcinoma cells (HepG2) was most affected by Cu-Cy-Nanos(P ＜0.05).Conclusion.:Cu-Cy-Nanos is a novel photosensitizer for the treatment of liver cancer.关键词
光动力学治疗/铜胺纳米材料/单线态氧Key words
photodynamic therapy/copper-cysteamine nanoparticles/singlet oxygen分类
医药卫生引用本文复制引用
黄雪静,何敏,周怡,臧宁,李洪涛,韦春梦,万逢洁..新型铜胺纳米材料抑制3种人类癌细胞增殖的实验研究[J].广西医科大学学报,2018,35(4):450-454,5.基金项目
广西壮族自治区科技厅重点研发项目(No.AB16380351) （No.AB16380351）
区域性高发肿瘤早期防治研究教育部重点实验室研究项目(No.GJZ201602) （No.GJZ201602）
区域性高发肿瘤早期防治研究广西重点实验室研究项目(No.GKZ201602) （No.GKZ201602）
广西高校高发疾病预防与控制重点实验室开放课题(No.02402214003-1502) （No.02402214003-1502）
