广西医学2018，Vol.40Issue(7)：759-762,4.DOI:10.11675/j.issn.0253-4304.2018.07.09
特利加压素联合人血白蛋白治疗肝硬化顽固性腹水的临床疗效
Clinical efficacy of terlipressin combined with human albumin for refractory ascites due to cirrhosis
摘要
Abstract
Objective To investigate the clinical efficacy of terlipressin combined with human albumin for refractory ascites due to cirrhosis.Methods A total of 282 patients with refractory ascites due to cirrhosis were randomly divided into control group and observation group,with 141 cases in each group. The control group was treated with human albumin on the basis of conventional treatment,the observation group was treated with terlipressin combined with human albumin on the basis of conventional treatment,and the treatment lasted for 14 days in both groups.The fasting body weight,abdominal circumference,ascites depth,24 h urine volume,diameter of portal system,serum albumin,creatinine and prothrombin time(PT) before and after treatment were compared,and clinical efficacy and incidence of complications were compared between the two groups.Results The body weight,abdominal circumference and ascites depth were lower while the 24 h urine volume was higher in the two groups after treatment in contrast with those before treatment,and the improvement in the observation group was more obvious than that in the control group(all P<0.05).The diameters of portal vein and splenic vein decreased in the two groups after treatment in contrast with those before treatment,and the diameters in the observation group was shorter than that in the control group (P<0.05).The levels of serum ALB increased while the levels of creatinine and PT decreased in both groups after treatment in contrast with those before treatment,and the improvement in the observation group was more obvious than that in the control group(all P<0.05). The total effective rate in the control group was lower than that in the observation group(P<0.05).No severe adverse reactions were found in the two groups during treatment.Conclusion Terlipressin combined with human albumin has a definite efficacy for refractory ascites due to cirrhosis,which can effectively improve the clinical and biochemical indicators and reduce the diameter of portal system.关键词
肝硬化顽固性腹水/特利加压素/人血白蛋白/白蛋白/肌酐/凝血酶原Key words
Refractory ascites due to cirrhosis/Terlipressin/Human albumin/Albumin/Creatinine/Prothrombin分类
医药卫生引用本文复制引用
张会涛,李秋雅,吕文浩,冯博帅,刁圣林..特利加压素联合人血白蛋白治疗肝硬化顽固性腹水的临床疗效[J].广西医学,2018,40(7):759-762,4.基金项目
河北省衡水市科技计划(2016014061Z) （2016014061Z）
