广西医学2018，Vol.40Issue(7)：785-787,3.DOI:10.11675/j.issn.0253-4304.2018.07.16
高危型人乳头瘤病毒E6/E7 mRNA联合薄层液基细胞学检测对宫颈癌前病变筛查的临床价值
Clinical value of high-risk human papilloma virus E6/E7 mRNA assay combined with Thinprep cytologic test in cervical precancerous lesion screening
颜霞 1唐海旭 1吴萍1
作者信息
- 1. 江苏省淮安市妇幼保健院病理科，淮安市223001
- 折叠
摘要
Abstract
Objective To investigate the clinical value of high-risk human papilloma virus(HR-HPV) E6/E7 mRNA assay combined with Thinprep cytologic test(TCT) in cervical precancerous lesion screening. Methods A total of 1 543 subjects accepted cervical precancerous lesion screening.Automatic nucleic acid detection system and TCT were respectively applied to detecting HR-HPV E6/E7 mRNA and precancerous lesions in the cervical specimens from the subjects.The detection rate and concordance rate of the two methods for cervical precancerous lesion screening were analyzed.Taking the results of pathologic biopsy as golden standard,the efficiencies of the two methods for cervical precancerous lesion screening were compared. Results No statistically significant difference was found in the positive detection rate between the two methods(P>0.05),and the concordance rate between the two methods was fair(P<0.05).The sensitivity of the combined detection was higher than that of TCT alone,and the specificity of the combined detection was lower than that of TCT or HR-HPV E6/E7 mRNA assay. The negative predictive value of the combined detection increased,while its positive predictive value decreased.Conclusion HR-HPV E6/E7 mRNA assay combined TCT is of greater value for cervical precancerous lesion screening.关键词
高危型人乳头瘤病毒E6/E7mRNA检测/液基细胞学/宫颈癌Key words
Human papilloma virus E6/E7 mRNA assay/Thinprep cytologic test/Cervical cancer分类
医药卫生引用本文复制引用
颜霞,唐海旭,吴萍..高危型人乳头瘤病毒E6/E7 mRNA联合薄层液基细胞学检测对宫颈癌前病变筛查的临床价值[J].广西医学,2018,40(7):785-787,3.
