广西医学2018，Vol.40Issue(8)：886-889,4.DOI:10.11675/j.issn.0253-4304.2018.08.06
口服匹多莫德联合布地奈德雾化吸入治疗儿童咳嗽变异性哮喘的临床效果
Clinical efficacy of oral administration of polimod combined with inhalation of budesonide for cough variant asthma in children
摘要
Abstract
Objective To explore the clinical efficacy of oral administration of polimod combined with inhalation of budesonide for cough variant asthma(CVA) in children.Methods Sixty-two children with CVA were randomly divided into control group(n=30) and observation group(n=32).Both groups received conventional therapy including inhalation of budesonide and anti-infection therapy. And the observation group was orally administrated polimod granule at the same time.Before and after 4 weeks of treatment,the lung function [including forced expiratory volume in one second(FEV1),peak expiratory flow(PEF) and FEV1/forced vital capacity ratio (FEV1/FVC)], inflammatory factors[including interleukin-5(IL-5),serum amyloid A(SAA) and procalcitonin(PCT)] levels,and cellular immune function (CD4+,CD8+and CD4+/CD8+) were compared between the two groups.The efficacy at 4 weeks after treatment and the recrudesce during 6-month follow-up were also compared between the two groups.Results After 4 weeks of treatment,FEV1,PEF,FEV1/FVC,CD4 +and CD4 +/CD8 +were higher and the levels of IL-5,SAA,PCT and CD8 +were lower in both groups compared to the levels before treatment (all P<0.05).In the observation group,FEV1,PEF,FEV1/FVC,CD4 +and CD4 +/CD8 +were higher and the levels of IL-5,SAA,PCT and CD8 +were lower than those in the control group(all P<0.05).The total effective rate of the observation group was higher than that of the control group(P <0.05),but there was no significant difference in the recrudesce rate between the two groups (P >0.05). Conclusion For the children with CVA,oral administration of polimod combined with inhalation of budesonide can achieve better control of clinical symptoms,improvement of immune function and lung function,and decreased levels of inflammatory factors,without severe adverse reactions.关键词
咳嗽变异性哮喘/匹多莫德/布地奈德/炎症因子/细胞免疫功能/肺功能/儿童Key words
Cough variant asthma/Polimod/Budesonide/Inflammatory factors/Cellular immune function/Lung function/Children分类
医药卫生引用本文复制引用
李丽华,黄秋芳..口服匹多莫德联合布地奈德雾化吸入治疗儿童咳嗽变异性哮喘的临床效果[J].广西医学,2018,40(8):886-889,4.基金项目
河北省科学技术研究与发展计划资金支持项目(13ZF128) （13ZF128）
