广西医学2018，Vol.40Issue(8)：890-893,4.DOI:10.11675/j.issn.0253-4304.2018.08.07
长方案体外受精-胚胎移植中诱发排卵次日血清β-人绒毛膜促性腺激素水平与临床结局的关系
Relationship between serum beta-human chorionic gonadotropin level after induced ovulation and clinical outcome in a prolonged protocol of in vitro fertilization and embryo transfer
摘要
Abstract
Objective To investigate the relationship between serum beta-human chorionic gonadotropin(β-HCG) level after induced ovulation by recombinant HCG and clinical outcome in a prolonged protocol of in vitro fertilization and embryo transfer(IVF-ET).Methods The clinical data of 907 patients treated with a prolonged protocol of IVF-ET were retrospectively analyzed.Induced ovulation by recombinant HCG was conducted in all cases.The patients were divided into group A(β-HCG<50 U/L,n=47),group B(50 U/L≤β-HCG<80 U/L,n=137), group C(80 U/L≤β-HCG<110 U/L,n=267),group D(110 U/L≤β-HCG<140 U/L,n=202) and group E(β-HCG≥140 U/L, n=254) according to the serum β-HCG level after induced ovulation.The use duration and consumption of gonadotropin,serum estradiol level and endometrial thickness at induced ovulation,rate of oocytes retrieval,rate of oocyte maturation,fertility rate,rate of high-quality embryo,clinical pregnancy rate,incidence rate of ovarian hyperstimulation syndrome(OHSS),and abortion rate were compared between the five groups.Results The rate of oocytes retrieval increased in the order of group A,group B,group,group D and group E(P<0.05).The use duration and consumption of gonadotropin,rate of oocyte maturation,and fertility rate of group A were higher than those of the other groups(P<0.05).There were no significant differences in the estradiol level or endometrial thickness at induced ovulation,number of transferred embryo on the 3rd day,rate of high-quality embryo,clinical pregnancy rate or abortion rate among the five groups (all P>0.05). Conclusion In the prolonged protocol of IVF-ET cycle,serum β-HCG level after induced ovulation by recombinant HCG is probably related to the rate of oocytes retrieval,but does not affect the clinical pregnancy rate.关键词
体外受精-胚胎移植/人绒毛膜促性腺激素/诱发排卵/获卵率/妊娠率Key words
In vitro fertilization-embryo transfer/human chorionic gonadotropin/Induced ovulation/Oocytes retrieval rate/Pregnancy rate分类
医药卫生引用本文复制引用
郭梅,黄品秀,韦立红,李忻琳..长方案体外受精-胚胎移植中诱发排卵次日血清β-人绒毛膜促性腺激素水平与临床结局的关系[J].广西医学,2018,40(8):890-893,4.基金项目
广西自然科学基金(2015GXNSFBA139177) （2015GXNSFBA139177）
广西柳州市科学研究与技术开发计划(2015J030515、2016G020217) （2015J030515、2016G020217）
广西医药卫生科研课题(Z2015180、Z2016553、Z2016554、Z2016555、Z2016556、Z2016557、Z2016558、Z2016559、Z2016560、Z2016561) （Z2015180、Z2016553、Z2016554、Z2016555、Z2016556、Z2016557、Z2016558、Z2016559、Z2016560、Z2016561）
