广西植物2018，Vol.38Issue(4)：457-462,6.DOI:10.11931/guihaia.gxzw201706019
大叶山楝根的化学成分及细胞毒活性研究
Chemical constituents and cytotoxic activities of roots from Aphanamixis grandifolia
摘要
Abstract
Aphanamixis grandifolia belongs to genus Aphanamixis of family Meliaceae.We made the experiment to clarify the constituents from the roots of A.grandifolia in this paper.The chemical constituents were isolated by silica gel,Seph?adex LH?20 column chromatographic methods.The structures were identified by spectral analysis and comparing with the previously reported literatures.The results showed that ten compounds were isolated from the ethyl acetate of ethanol ex?tract from A. grandifolia and identified respectively as schleicheol(1),β?rosasterol(2), fregenedadiol(3), isojaca?reubin(4),syringaresinol(5),episyringaresinol(6),graminone A(7),sylvatesmin(8),methyl?Z?6?nonadecenoate (9),ralmitic acid(10). The compounds 1-4,7-9 were obtained from A. grandifolia for the first time. The results of cytotoxic activity showed that compounds 1 and 2 had certain inhibitory activity on the growth of human gastric cancer cell SGC?7901.关键词
楝科/大叶山楝/化学成分/细胞毒活性Key words
Meliaceae/Aphanamixis grandifolia/chemical constituents/cytotoxic activity分类
农业科技引用本文复制引用
李薇,黄淼,梅文莉,董文化,王军,蔡彩虹,盖翠娟,戴好富..大叶山楝根的化学成分及细胞毒活性研究[J].广西植物,2018,38(4):457-462,6.基金项目
国家公益性行业(农业)科研专项项目(201303117) （农业）
海南省重点研发计划项目(ZDYF2016140) （ZDYF2016140）
海南自然科学基金(2017CXTD020)[Supported by Special Fund for Agro?Scientific Research in the Public Interest(201303117) （2017CXTD020）
Special Fund for Key Re?search Program of Hainan Province(ZDYF2016140) （ZDYF2016140）
Natural Science Foundation of Hainan(2017CXTD020)]. （2017CXTD020）
