广西植物2018，Vol.38Issue(4)：469-474,6.DOI:10.11931/guihaia.gxzw201709002
鸭儿芹的化学成分及对Hep G2细胞毒性
Chemical c constituents of Cryptotaenia japonica and toxicity to Hep G2
摘要
Abstract
Chemical constituents of Cryptotaenia japonica were separated and purified by macroporous resin D101,silica gel chromatography,Sephadex LH?20 and octadecylisilyl(ODS). Component structures were identified by physical and chemical properties,using spectral analysis included MS and NMR.MTT method was used to evaluate anti?tumor activi?ties of chemical components. The results were as follows:Seven constituents were obtained from C.japonica. The struc?tures were identified as p?(acetylamino)phenol(1), methyl caprylate(2),isopentyl butyrate(3), N,N?dimethyl?1H?benzo[d]imidazol?2?amine(4),5?hydroxy?1?(4?hydroxy?3?methoxyphenyl)heptan?3?one(5),(3R?,5S?,7aR)?3,5?dibutylhexahydro?1H?pyrrolizine(6),(S)?4?(1?hydroxy?allyl)phenyl acetate(7). Componds 1-7 were obtained for the first time from C. japonic. Component 6 showed significant inhibitory effect against Hep G2 with the inhibition ratio 89.1% and had dose?dependent effect.关键词
鸭儿芹/化合物/抗肿瘤活性Key words
Cryptotaenia japonica/compond/anti⁃tumor activity分类
农业科技引用本文复制引用
刘安韬,张婷,梁杏梅..鸭儿芹的化学成分及对Hep G2细胞毒性[J].广西植物,2018,38(4):469-474,6.基金项目
广西自然科学基金青年基金(2014GXNSFBA118202)[Supported by Guangxi Natural Science Foundation for Young Scholars(2014GXNSFBA118202)]. （2014GXNSFBA118202）
