中北大学学报（自然科学版）2018，Vol.39Issue(2)：230-235,240,7.DOI:10.3969/j.issn.1673-3193.2018.02.021
交联壳聚糖季铵盐薄膜的表征与性能
Characterization and Properties of Cross-linked Chitosan Quaternary Ammonium Salt Film
摘要
Abstract
An antibacterial cross-linked chitosan quaternary ammonium salt was prepared using epichlo-rohydrin as cross-linking agent and reacting with chitosan quaternary ammonium salt by chemical cross-linking and solution casting method.ATR-FTIR,1H NMR,SEM,equilibrium swelling method,plate count method and broth microdilution method were applied to analysis the structure,morphology,water stability and antimicrobial activity of cross-linked chitosan quaternary ammonium salt film.The results show that the amount of cross-linking agent is proportional to the cross-linking degree of the film.Com-pare with the chitosan quaternary ammonium salt film,cross-linked chitosan quaternary ammonium salt films only swell and not dissolve in water.And it maintains excellent antibacterial activity against E.co-li,S.aureus and P.and aeruginosa,the minimum inhibitory concentrations are 320,2 560 and 160 μg/mL,respectively.Prepared cross-linked chitosan quaternary ammonium salt can be used as anti-bacterial coating,filter membrane and drug delivery carrier,which can be applied in food packaging, water treatment,pharmaceutical and other fields.关键词
壳聚糖季铵盐(HTCC)/抗菌涂层/交联壳聚糖季铵盐(CHTCC)/环氧氯丙烷Key words
chitosan quaternary ammonium salt/antibacterial coating/cross-linked chitosan quaternary ammonium salt/epichlorohydrin分类
化学化工引用本文复制引用
解冰,夏凯,赵春毛,李洁..交联壳聚糖季铵盐薄膜的表征与性能[J].中北大学学报（自然科学版）,2018,39(2):230-235,240,7.基金项目
山西省国际科技合作资助项目(201703D421007) （201703D421007）
中北大学科学研究基金资助项目(2017010) （2017010）
