湖南中医药大学学报2018，Vol.38Issue(5)：489-492,4.DOI:10.3969/j.issn.1674-070X.2018.05.001
双丹明目胶囊对糖尿病视网膜病变大鼠血糖血脂及血液流变学的影响
Effects of Shuangdan Mingmu Capsule on Blood Glucose, Blood Lipid and Blood Rheology in Diabetic Retinopathy Rats
摘要
Abstract
Objective To observe the effects of Shuangdan Mingmu capsule on blood glucose, blood lipid and blood rheology, and to explore its possible mechanism of treatment. Methods SD rats were injected with STZ (50 mg / kg) into the tail vein to induce diabetic model with retinopathy. The rats were randomly divided into model group, high dose, medium dose and low dose of Shuangdan Mingmu capsule groups and positive drug group, normal rats as controls. After continuous administration for 30 days, the blood glucose and blood lipid of rats were measured by biochemical method. The hemorrheological indexes were tested such as whole blood viscosity (WBV), plasma viscosity (PV), erythrocyte sedimentation rate (ESR), hematocrit (HCT) and fibrinogen (FIB). Results Compared with the normal group, the levels of blood glucose, total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL-C) in model group increased significantly (P<0.01) and high-density lipoprotein (HDL-C) levels decreased significantly (P<0.01). The levels of WBV, PV, ESR, HCT, FIB increased obviously (P<0.01 or P<0.05). After administration of Shuangdan Mingmu capsule, blood glucose, TC, TG, LDL-C levels of model rats decreased (P<0.05), HDL-C increased (P<0.05), the levels of WBV, PV, ESR, HCT, FIB declined (P<0.05). Conclusion The mechanism of Shuangdan Mingmu capsule in the treatment of DR might be related to the effective improvement of blood glucose and lipid disorders, and abnormal blood rheology in DR rats.关键词
糖尿病视网膜病变/双丹明目胶囊/血糖/血脂/血液流变学Key words
diabetic retinopathy/Shuangdan Mingmu capsule/blood glucose/blood lipid/blood rheology分类
医药卫生引用本文复制引用
符超君,凌艳君,颜家朝,赵永旺,刘峥嵘,秦裕辉..双丹明目胶囊对糖尿病视网膜病变大鼠血糖血脂及血液流变学的影响[J].湖南中医药大学学报,2018,38(5):489-492,4.基金项目
国家自然科学基金面上项目(81473737) （81473737）
湖南省研究生创新课题(CX2016B353). （CX2016B353）
