基础医学与临床2018，Vol.38Issue(5)：708-712,5.
ACE/AngⅡ/AT1轴和ACE2/Ang(1-7)/Mas轴对脂肪组织糖脂代谢的影响
Effect of ACE/Ang Ⅱ/AT1 axis and ACE2/Ang(1-7)/Mas axis on glucose and lipid metabolism in adipose tissue
摘要
Abstract
The renin angiotensin system(RAS)includes two counterbalance axes:the ACE/Ang Ⅱ/AT1 axis and the ACE2/Ang(1-7)/Mas axis.The RAS can regulate glucose and lipid metabolism in adipose tissue.Most of evi-dences demonstrated that the ACE/Ang Ⅱ/AT1 axis can induce glucose metabolism disorders in adipose tissue, while ACE2/Ang(1-7)/Mas axis improves glucose metabolism.The RAS,which is over activated in obese patient, has been considered to be a potential link among obesity,dyslipidemia and insulin resistance.The effect of ACE/AngⅡ/AT1 axis and ACE2/Ang(1-7)/Mas axis on lipid and glucose metabolism in adipose tissue should be futh-er investigated,and we may find a new target for improving glucose and lipid metabolism.关键词
肾素-血管紧张素系统/ACE/AngⅡ/AT1轴/ACE2/Ang(1-7)/Mas轴/脂肪组织/糖脂代谢Key words
renin-angiotensin system/ACE/AngⅡ/AT1 axis/ACE2/Ang(1-7)/Mas axis/adipose tissue/glucose and lipid metabolism分类
医药卫生引用本文复制引用
马池发,史婷婷,袁明霞..ACE/AngⅡ/AT1轴和ACE2/Ang(1-7)/Mas轴对脂肪组织糖脂代谢的影响[J].基础医学与临床,2018,38(5):708-712,5.基金项目
国家自然科学基金(81370946) （81370946）
