基础医学与临床2018，Vol.38Issue(5)：727-730,4.
跨损伤合成DNA聚合酶ζ-Rev7在肿瘤发展中的研究进展
Research progress on translesion synthesis DNA polymerase ζ-Rev7 in tumor development
曹菊华 1汪良芝2
作者信息
- 1. 中国人民解放军第102医院内科,江苏常州213003
- 2. 苏州大学附属第三医院老年医学科,江苏常州213003
- 折叠
摘要
Abstract
Translesion DNA synthesis is a kind of post-replication repair process, which mainly involves DNA polymerase kappa, eta and zeta.Translesion synthesis is a tolerance mechanism of DNA damage inside the cell, in which DNA polymerase zeta plays an important role.DNA polymerase zeta is mainly composed of subunits Rev7 and Rev3, and play a main role of participate in the damage repair in cell metabolism.Rev7(also known as MAD2L2)is a multifunctional protein that can be combined with a variety of proteins to participate in DNA dam-age repair, cell cycle regulation, gene expression and carcinogenesis, which is also involved in the prognosis of various adverse tumors.关键词
DNA聚合酶ζ/Rev7/肿瘤Key words
DNA polymerase zeta ζ/Rev7/tumor分类
医药卫生引用本文复制引用
曹菊华,汪良芝..跨损伤合成DNA聚合酶ζ-Rev7在肿瘤发展中的研究进展[J].基础医学与临床,2018,38(5):727-730,4.
