解剖学杂志2018，Vol.41Issue(2)：135-138,4.DOI:10.3969/j.issn.1001-1633.2018.02.002
DBA/2J小鼠耳蜗毛细胞静纤毛早期的形态结构变化
Early changes of morphological structures of cochlear hair cell stereocilia in DBA/2J mice
摘要
Abstract
Objective:To observe the features of morphological structure of cochlear hair cell stereocilia in DBA/2J mice at early ages and to discuss the causes of progressive hearing loss.Methods:The auditory brainstem response was tested to evaluate the hearing of mice at the age of 3,4 weeks and 8 weeks.Then,scanning electron microscopy was used to observe the images of hair cell stereocilia.Results:DBA/2J mice showed progressive hearing loss starting at the age of 4 weeks.Pathological features of the stereocilia in DBA/2J mice at different ages were revealed by scanning electron microscope.At 2 weeks of age,some of the stereocilia bundles were fused and softened at high magnification.At 4 weeks of age,stereocilia bundles became more fused,softened and lodged at high magnification.At 8 weeks of age,the number of missing stereocilia bundles grew bigger and the remaining bundles became more lodged at low magnification-Conclusion:The fusion,softening,lodging and missing of stereocilia bundles may be the causes of early onset hearing loss in DBA/2J mice.关键词
年龄相关性听力损失/耳蜗/毛细胞/静纤毛/扫描电镜/DBA/2J小鼠Key words
age-related hearing loss/cochlea/hair cell/stereocilia/scanning electron microscopy/DBA/2J mouse引用本文复制引用
刘祥,金昌洙,韩锋产..DBA/2J小鼠耳蜗毛细胞静纤毛早期的形态结构变化[J].解剖学杂志,2018,41(2):135-138,4.基金项目
国家自然科学基金(81771020,81570927) （81771020,81570927）
