军事医学2018，Vol.42Issue(1)：13-16,4.DOI:10.7644/j.issn.1674-9960.2018.01.004
壳聚糖复合KGF-2突变体温敏敷料研制及初步评价
Preparation and preliminary evaluation of chitosan composite KGF-2 mutant thermal sensitive dressing
摘要
Abstract
Objective To develop chitosan composite keratinocyte growth factor-2 mutant(KGF-2M)temperature-sen-sitive dressing and evaluate its physicochemical properties and dynamic release rule were used.Methods Chitosan, chi-tosan quaternary ammonium salt,β-glycerophosphate and other adjuvant materials to configure different formulations which were compounded with KGF-2M in order to develop temperature-sensitive dressing.Gelling time, temperature,the release rate of KGF-2M and other indicators were measured to analyze the physical and chemical properties of the temperature -sen-sitive dressing.Results Chitosan-KGF-2M composite dressing with temperature-sensitive properties was obtained by opti-mizing the formulation components of chitosan and related adjuvant materials.When the liquid dressing was above 35℃,it could be converted from liquid to solid gelatin within 10 minutes.The compound KGF-2M released from the gel was more than 98%at 4 h,and its bioactivity remained stable.Conclusion The thermo-sensitive gel has the characteristics of good conformability,moisturizing(moisture),isolation,wound healing,and a controlled release effect,which has great potential in wartime for wound repair.关键词
复合敷料/温敏凝胶/壳聚糖/角质细胞生长因子2/突变体Key words
composite dressing/temperature-sensitive gel/chitosan/keratinocyte growth factor-2/mutant分类
医药卫生引用本文复制引用
付文亮,景浩然,邹民吉,陈惠华,夏文戎,邢微微,周丽君,徐东刚..壳聚糖复合KGF-2突变体温敏敷料研制及初步评价[J].军事医学,2018,42(1):13-16,4.基金项目
军队重点课题资助项目(BHJ14J004) （BHJ14J004）
