检验医学与临床2018，Vol.15Issue(9)：1217-1219,1223,4.DOI:10.3969/j.issn.1672-9455.2018.09.001
血清抑制性G蛋白α亚基-2在2型糖尿病合并不同分级高血压患者中的变化及意义
Changes and clinical value of serum Gi α-2 in patients with type 2 diabetes and different classification of hypertension
摘要
Abstract
Objective To investigate the changes and its clinical value of serum Giα-2 in type 2 diabetes and different classification of hypertension.Methods A total of 197 patients with type 2 diabetes were selected in-to this study,including 45 cases of simple diabetes patients(DS group),47 cases of diabetic and grade 1 hyper-tension patients(DH1 group),51 cases of diabetic and grade 2 hypertension patients(DH2 group)and 54 ca-ses of diabetic and grade 3 hypertension patients(DH3 group).A total of 40 healthy people were enrolled in this study as normal control(NS group).The serum Giα-2 level of subjects was detected by ELISA.The rela-tionships of Giα-2 and each influencing factor were analyzed by Multiple Linear Regression.Results The level of Giα-2 in DS group was lower than that in NS group,at the same time,the levels of Giα-2 in DH1,DH2 and DH3 group were higher than that of DS group,and when blood pressure increased,Giα-2 increased,and the highest level of Giα-2 was in DH3 group(P<0.05).The result of the multivariate linear regression analysis showed that Giα-2 positively correlated with SBP(r=0.54,P<0.05).Further multiple linear regression anal-ysis showed that Giα-2 level was an independent risk factor of SBP.Conclusion Giα-2 might closely related to the occurrence and development of diabetes and hypertension.关键词
抑制性G蛋白α亚基-2/2型糖尿病/不同分级/高血压Key words
Giα-2/type 2 diabetes/different classification/hypertension分类
医药卫生引用本文复制引用
马爽,李宝新,张云良,常文龙,王翯,张鑫,郭淑芹..血清抑制性G蛋白α亚基-2在2型糖尿病合并不同分级高血压患者中的变化及意义[J].检验医学与临床,2018,15(9):1217-1219,1223,4.基金项目
国家自然科学基金资助项目(81500644) （81500644）
河北省医学科学研究重点课题计划项目(20160282). （20160282）
