检验医学与临床2018，Vol.15Issue(9)：1220-1223,4.DOI:10.3969/j.issn.1672-9455.2018.09.002
下肢深静脉血栓形成患者凝血酶-抗凝血酶复合物的变化及在抗凝治疗中的价值
The changes of thrombin-antithrombin complex level in critically ill patients with deep vein thrombosis and its values in anticoagulant treatment
摘要
Abstract
Objective To investigate the value of thrombin-antithrombin complex(TAT)for evaluating the risk of lower extremity deep vein thrombosis(DVT)and the efficacy of anticoagulant treatment in critical-ly ill patients.Methods Sixty critically ill patients who stayed in the ICU for more than one week were col-lected from January to May in 2017,in which fourteen cases were diagnosed with DVT,called thrombus group,forty-six cases were diagnosed without DVT,called control group.TAT,thrombotic protein(TM),D-Dimer(D-D),fibrin(original)degradation product(FDP)were measured in all patients when suspected they had thrombosis.Low-molecular-weight heparin were given to the patients in thrombus group and then detec-ted the plasma levels of TAT,D-D and FDP on the second day after treatment.Results The plasma levels of TAT,TM,D-D and FDP in thrombus group were significantly higher than those of control group(P<0.05). As to TM,there was no significant difference between the two groups(P= 0.332).The receiver operating characteristic(ROC)curve analysis suggested that the area under the ROC curve of TAT,D-D and FDP in the diagnosis of DVT were 0.901,0.726 and 0.753 respectively(P<0.05).Among these parameters,only TAT decreased obviously after anticoagulant treatment compared with that before anticoagulant treatment(P<0.05).Conclusion T A T could be used as a valuable predictor of DV T in ICU patients,and it could be also used to judge the anticoagulation efficacy in DV T patients.关键词
凝血酶-抗凝血酶复合物/D-二聚体/纤维蛋白(原)降解产物/深静脉血栓形成Key words
thrombin-antithrombin complex/D-Dimer/fibrin(original)degradation products/deep venous thrombosis分类
临床医学引用本文复制引用
廉应涛,何川,余追,姚兰,左小淑,侯果..下肢深静脉血栓形成患者凝血酶-抗凝血酶复合物的变化及在抗凝治疗中的价值[J].检验医学与临床,2018,15(9):1220-1223,4.基金项目
湖北省自然科学基金资助项目(2011CDB479). （2011CDB479）
