检验医学与临床2018，Vol.15Issue(9)：1232-1234,1238,4.DOI:10.3969/j.issn.1672-9455.2018.09.005
抗凝血酶Ⅲ对预测性诊断孕产妇脑静脉窦血栓的价值分析
Value of antithrombin Ⅲ in predicting cerebral venous sinus thrombosis in pregnant women
摘要
Abstract
Objective To investigate the predictive value of plasma antithrombin Ⅲ(ATⅢ)in the diagno-sis of cerebral venous sinus thrombosis(CVST)in pregnant women.Methods A total of 137 pregnant women who received first production inspection in our hospital from January 2012 to January 2017 were involved to carry out prospective follow-up study.These subjects all showed that D-Dimer(D-D)was above 4 mg/L or fi-brinogen degradation products(FDP)was above 4 mg/L.According to whether CVST occurred,they were di-vided into observation group(n=21,CVST occurred)and control group(n=116,CVST did not occur).Their platelet count(PLT),prothrombin time(PT),D-D,FDP,AT Ⅲ were detected and compared,the correlation among ATⅢ and other indexes were analyzed,the predictive value of AT Ⅲ in the diagnosis of CVST were an-alyzed by receiver operating characteristic(ROC)curve,the relationship between AT Ⅲ and CVST were ana-lyzed by binary logistic regression.Results ATⅢ in the observation group was much lower,and PT was much longer than those in the control group,the differences were statistical significant(P<0.05).ATⅢ negatively correlated with PT(r= -0.806,P=0.001).AT Ⅲ had reliable value for early diagnosis of CVST,the area under ROC was 0.849,and the optimal cutoff value of AT Ⅲ was 72.8%,where the sensitivity was 0.857,and the specificity was 0.698.Low AT Ⅲ was an independent risk factor for CVST(OR=2.711,P=0.001).Conclusion The detection of AT Ⅲ in early pregnancy has certain value for early diagnosis of CVST.It is suggested that for cases with dysfunction of coagulation and fibrinolysis,AT Ⅲ should be detected at the same time.关键词
抗凝血酶Ⅲ/孕产妇/脑静脉窦血栓Key words
antithrombin Ⅲ/pregnant women/cerebral venous sinus thrombosis分类
医药卫生引用本文复制引用
毕瑞,张波,尹建威,杨亮..抗凝血酶Ⅲ对预测性诊断孕产妇脑静脉窦血栓的价值分析[J].检验医学与临床,2018,15(9):1232-1234,1238,4.基金项目
陕西省医学科技攻关计划项目(201405107). （201405107）
