Abstract
Objective To investigate the application effects of solifenacin combined with tamsulosin in mild and moderate benign prostatic hyperplasia with overactive bladder.Methods A total of 160 patients with mild and moderate benign prostatic hyperplasia and overactive bladder were chosen as experimental subjects,mild patients were divided into research group one and control group one,moderate patients were divided into re-search group two and control group two,each group were 40 cases,patients in research group were treated with solifenacin(5 mg each time,once per day)combined with tamsulosin(0.2 mg each time,once per day), patients in control group were treated with tamsulosin(0.2 mg each time,once per day),after 12 weeks'treat-ment,residual urine,Qmax,Voiding symptom score(VSS),Urine storage period symptom score(USPSS), Overactive bladder symptom score(OABSS),International Prostate Symptom Score(IPSS)and adverse reac-tions were compared.Results Before treatment,IPSS,USPSS,OABSS,residual urine and Qmax between re-search group one and control group one had no significant differences(t=0.333,0.448,0.269,0.081,0.384, P>0.05).After treatment,IPSS,USPSS,OABSS of research group one were lower than those in the control group one,Qmax was higher than that in the control group one,the differences were statistically different(t=8.692,8.095,9.264,6.065,P<0.05).Residual urine between two groups had no significant difference(t=0.081,0.456,P> 0.05).Before treatment,IPSS,VSS,OABSS,residual urine and Qmax between research group two and control group two had no significant difference(t=1.253,0.139,0.092,0.006,0.619,P>0. 05).After treatment,IPSS,VSS,residual urine and Qmax between the two groups had no significant differ-ences(t=0.096,1.678,0.478,0.456,P>0.05).OABSS of research group two was lower than that in the control group,the difference was statistically different(t=4.222,P<0.05).In mild and moderate patients, adverse reaction rate between research group one and control group one(12.50% vs.7.50%),research group two and control group two(10.00% vs 7.50%)had no significant differences(χ2=0.556,0.157,P>0.05). Conclusion Solifenacin combined with tamsulosin could effectively improve the clinical symptom of mild and moderate benign prostatic hyperplasia with overactive bladder,and with good safety,worthy of clinical promo-tion.关键词
前列腺增生/良性/膀胱过度活动症/索利那新/坦索罗辛Key words
prostatic hyperplasia/benign/overactive bladder/tamsulosin/solifenacin分类
医药卫生
