临床误诊误治2018，Vol.31Issue(3)：73-76,4.DOI:10.3969/j.issn.1002-3429.2018.03.023
不同剂量瑞舒伐他汀对急性冠状动脉综合征介入术后血脂、炎症因子及心功能影响
Effects of Different Doses of Rosuvastatin on Serum Lipids, Serum Inflammatory Factors and Cardiac Function after Percutaneous Coronary Intervention in Patients with Acute Coronary Syndromes
摘要
Abstract
Objective To investigate the effects of different doses of Rosuvastatin on serum lipids,serum inflammatory factors and cardiac function after percutaneous coronary intervention (PCI) for treating acute coronary syndrome (ACS).Methods A total of 100 patients with ACS who underwent PCI in our hospital from February 2015 to August 2017 were divided into standard-treatment group (n =50) and intensive-treatment group (n =50)based on table of random digits.Rosuvastatin was given orally at 7 d before operation in both groups.On this basis,oral administration of Rosuvastatin 10 mg/d in the standard group and Rosuvastatin 20 mg/d in the intensive group were continued for 30 d after operation.Blood lipid,inflammatory factors and cardiac function were compared in the two groups.Results Compared with those before operation,the levels of total cholesterol (TC),triglyceride (TG),low density lipoprotein cholesterol (LDL-C),left ventricular end-systolic diameter (LVESD),left ventricular end-diastolic diameter (LVEDD),and the levels of tumor necrosis factor-α (TNF-α),hs-CRP and interleukin-6 (IL-6) at 30 d after operation were significantly decreased (P ＜ 0.05),whereas the levels of HDL-C and left ventricular ejection fraction (LVEF) were increased remarkably (P ＜ 0.05).Compared with the standard group,the levels of TC,TG,LDL-C,LVESD and LVEDD at 30 d after operation and the levels of TNF-α,hs-CRP and IL-6 at 7 d after operation were decreased,whereas the levels of HDL-C and LVEF at 30 d after operation in the intensive-treatment group were increased significantly (P ＜0.05).Conclusion Rosuvastatin can improve the level of blood lipids,inhibit the inflammatory reaction and protect the heart function of ACS patients after PCI,producing more pronounced effect after intensive treatment.关键词
急性冠状动脉综合征/经皮冠状动脉介入术/瑞舒伐他汀/肿瘤坏死因子-αKey words
Acute coronary syndrome/Percutaneous coronary intervention/Rosuvastatin/Tumor necrosis factor-alpha分类
医药卫生引用本文复制引用
范群雄,赵继先,张焕鑫,李波,陈昆..不同剂量瑞舒伐他汀对急性冠状动脉综合征介入术后血脂、炎症因子及心功能影响[J].临床误诊误治,2018,31(3):73-76,4.基金项目
湖北省卫生厅计划项目(鄂卫2015-53) （鄂卫2015-53）
