南京大学学报（自然科学版）2018，Vol.54Issue(3)：612-621,10.DOI:10.13232/j.cnki.jnju.2018.03.017
辛酸甲酯合成新工艺的研究
Study on the new synthesis method of n-caprylic acid esterification
摘要
Abstract
As an important fine chemical products,n-caprylic acid esterification has special application value in many fields such as synthetic cosmetics and pharmaceutical intermediates due to its good reactivity.Concentrated sulfuric acid is generally used as catalyst in the traditional production process of n-caprylic acid esterification,which can result in many serious problems,such as strong corrosiveness to the experimental apparatus,difficult catalyst recovery,serious environmental pollution,etc.So that the traditional production process is not consistent with the current requirements of green,economy and sustainable development.On the contrary,the strong acid macroporouscation exchange resin is widely used as an ideal catalyst due to its many excellent properties,including high catalytic activity and selectivity,good chemical stability,non-corrosiveness to equipment,no"three wastes",and easy separation.Effects of catalyst amount,ratio of the solvent to substrate,temperature,circulating flowofthe intensified reactor andcatalyst cycles were explored to obtain a suitable reaction system.Besides,the thermodynamic and kinetic parameters of the esterification process were further calculated.It could be seem that the experimental values were almost consistent with the theoretical ones,which provided powerful guidance for the industrial applicationof n-caprylic acid esterification.关键词
辛酸甲酯/条件优化/工艺研究/动力学Key words
n-caprylic acid esterification/conditional optimization/synthesis technology/kinetics分类
化学化工引用本文复制引用
刘承智,杨高东,周政,张志炳,梁银春..辛酸甲酯合成新工艺的研究[J].南京大学学报（自然科学版）,2018,54(3):612-621,10.基金项目
国家自然科学基金(21476105) （21476105）
