实验动物与比较医学2018，Vol.38Issue(2)：122-125,4.DOI:10.3969/j.issn.1674-5817.2018.02.008
B6-St小鼠与C57BL/6小鼠周围神经再生能力的比较
Comparison of Peripheral Nerve Regeneration Ability in B6-St mice and C57BL/6 Mice
吴刘成 1杨文杰 2范海华 2易剑峰 2田家玮 3史祎敏 3蒋茂荣1
作者信息
- 1. 南通大学实验动物中心,南通226001
- 2. 南通大学医学院,南通226001
- 3. 南通大学杏林学院,南通226001
- 折叠
摘要
Abstract
Objective To explore the difference of peripheral nerve regeneration between C57BL/6 mice and B6-St mice (short tail mice) comparing sciatic nerve injury mice model.Methods Healthy C57BL/6 mice and B6-St mice were selected for study.Each group was half the male and female.All the mice were treated with left sciatic nerve injury to induce the model mice which were followed up for 8,12 and 16 days after surgery to calculate the sciatic function index (SFI).All mice were subjected to electrophysiological examination 21 days after the operation.The composite muscle motion potentials (CMAPs) were recorded.The bilateral gastrocnemius muscle of each group was used to calculate the wet weight ratio of gastrocnemius muscle.The frozen gastrectomy was performed on the gastrocnemius muscle.The cross-sectional area (CSA) of the muscle fibers was measured by HE staining.Results The SFI values of the two groups were not significantly different on 8,12 and 16 days after operation (P＞0.05).There was no significant difference in the composite muscle between the two groups (P＞0.05).There was no significant difference between the two groups in terms of the wet weight of the gastrocnemius muscle.There was no significant difference in the CSA between the two groups.Conclusion The peripheral nerve regeneration ability of B6-St mice is similar to that of C57BL/6 mice.关键词
B6-St小鼠/周围神经再生/坐骨神经功能指数(SFI)/复合肌动作电位(CMAPs)Key words
B6-St mice/Peripheral nerve regeneration/Sciatic function index (SFI)/Compound muscle action potentials (CMAPs)分类
生物科学引用本文复制引用
吴刘成,杨文杰,范海华,易剑峰,田家玮,史祎敏,蒋茂荣..B6-St小鼠与C57BL/6小鼠周围神经再生能力的比较[J].实验动物与比较医学,2018,38(2):122-125,4.
