同济大学学报（医学版）2018，Vol.39Issue(2)：7-11,5.DOI:10.16118/j.1008-0392.2018.02.002
益赛普联合甲氨蝶呤治疗中重度斑块型银屑病的有效性和安全性
Efficacy and safety of etanercept combined with methotrexate in treatment of moderate to severe plaque psoriasis
摘要
Abstract
Objective To evaluate the efficacy and safety of etanercept combined with methotrexate (MTX)in treatment of moderate to severe plaque psoriasis. Methods Thirty patients with moderate to severe plaque psoriasis were divided into two groups:15 patients in combination group were treated by etanercept with MTX, and 15 patients in monotherapy group were treated by etanercept alone. Patients of both group used drugs for 24 weeks. The PASI scores were documented and PASI 50,PASI 75 and PASI 90 proportions were calculate at week 0, 2, 6, 12, 18 and 24. The physician's global assessment(PGA), patient's global assessment(PtGA)and dermatology life quality index(DLQI) were evaluated at the same time points. The blood routine, liver and kidney function, blood sedimentation and C-reactive protein were measured at week 0, 2, 6, 12, 18, 24. Adverse events including infection, tumor, headache, abnormal liver function were recorded. Results The PASI scores of combination group and monotherapy group at week 0 were 28.97 ± 7.09 and 30.31 ± 9.32, respectively(P>0.05). The PASI score of combination group at week 24 was significantly lower than that of monotherapy group(5.31 ± 2.35 vs 7.10 ± 2.94, P<0.05). The PASI 75 of the two groups were 66.7% and 46.7% at week 12,80.0% and 66.7% at week 24,indicating that the efficacy of the combination group was better than the monotherapy group. The incidence of adverse events in combination group and in monotherapy group was 60%and 33.3%,respectively;however,all adverse events were mild to moderate,no severe infections and tumor occurred during the period of treatment. Conclusion Etanercept combined with methotrexate had better efficacy and good safety with slightly increased adverse reactions in treatment of patients with moderate to severe plaque psoriasis.关键词
银屑病/斑块/益赛普/甲氨蝶呤Key words
psoriasis/plaque/etanercept/methotrexate分类
医药卫生引用本文复制引用
张玲玲,龚瑜,于倩,王瑶,史玉玲..益赛普联合甲氨蝶呤治疗中重度斑块型银屑病的有效性和安全性[J].同济大学学报（医学版）,2018,39(2):7-11,5.基金项目
国家自然科学基金(81301356) （81301356）
上海市自然科学基金(13ZR1432200,16ZR1426800) （13ZR1432200,16ZR1426800）
上海市科委引导项目基金(13411960700) （13411960700）
